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《Chongqing Medicine》 2007-04
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Screen of significant genes with adjustable FPR based on microarray data

ZHANG Yan-qi,YUAN Yuan,ZHAO Zeng-wei,et al.(1.Department of Health Statistics,College of Preventive Medicine,Third Military Medical University,Chongqing 400038,China;2.Rongsheng Pharmaceulicals Company Limited,Chengdu 610000,China)  
Objective To search an effective method on screening significant genes based on microarray data.Methods Based on conventional t test,ANOVA and random combined microarray data,the rank statistic and expected rank statistic were constructed.Though adjusting the difference of the two statistics and taking it as a threshold,the corresponding FPR(false positive rate) was computed and the significant genes were screened.Results With the method used on simulative data and real microarray data,idealized operation result was made.Conclusion The method is suitable to analyze microarray data and screen significant genes.Besides,the method is more flexible than conventional methods.
【Fund】: 国家自然基金资助课题(60371034)
【CateGory Index】: Q78
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【Secondary References】
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