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《Chongqing Medicine》 2007-04
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Screen of significant genes with adjustable FPR based on microarray data

ZHANG Yan-qi,YUAN Yuan,ZHAO Zeng-wei,et al.(1.Department of Health Statistics,College of Preventive Medicine,Third Military Medical University,Chongqing 400038,China;2.Rongsheng Pharmaceulicals Company Limited,Chengdu 610000,China)  
Objective To search an effective method on screening significant genes based on microarray data.Methods Based on conventional t test,ANOVA and random combined microarray data,the rank statistic and expected rank statistic were constructed.Though adjusting the difference of the two statistics and taking it as a threshold,the corresponding FPR(false positive rate) was computed and the significant genes were screened.Results With the method used on simulative data and real microarray data,idealized operation result was made.Conclusion The method is suitable to analyze microarray data and screen significant genes.Besides,the method is more flexible than conventional methods.
【Fund】: 国家自然基金资助课题(60371034)
【CateGory Index】: Q78
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【References】
Chinese Journal Full-text Database 1 Hits
1 WU Yazhou,ZHANG Ling,YI Dong,LIU Ling Department of Health Statistics,Military Preventive Medicine College,Third Military Medical University,Chongqing 400038;Identifying differential expression genes based-wavelet transform & SAM methods[J];Beijing Biomedical Engineering;2008-05
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LIU Qi rong, ZHANG Xiao rong, WANG Yang. (Chongqing Forth People's Hospital, Chongqing 400014, China);Clinical investigation on treatment of alcoholic fatty liver with Tiopronin[J];Chongqing Medical Journal;2003-10
2 ZHANG Ju ,CHEN Xiao-pin (Department of Oncology,the First Affiliated Hospital,Chongqing University of Medical Sciences, Chongqing 400016,China);Clinicopathologic characteristics and treatment of central neurocytoma[J];Chongqing Medical Journal;2005-01
3 CHEN Shi-yu,YI Feng-Qiong,ZHANG Ming(Department of Anesthesiology,First Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing 400016,China);Comparison study of sanitizing effect of dynamic air disinfection with static air disinfection in operating room[J];Chongqing Medicine;2006-03
4 DENG Jun,XIANG Gui-ping,HUANG Ji (1.Department of Cardiology,Sixth People′s Hospital of Chongqing,Chongqing 400060,China;2.Department of Cardiology,Southwest Hospital,Third Military Medical University,Chongqing 400038,China);Relationship between heme oxygenase/carbon monoxide and nitricoxide synthase/nitrogen monoxide system in atherosclerotic progress[J];Chongqing Medicine;2006-23
5 YANG Wen-lin,CHEN Guo-ming,LIU Qi,et al.(1.Department of Nuclear Medicine,Second Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing 400010,China;2.Institute for Viral Hepatitis,Chongqing University of Medical Sciences,Chongqing 400010,China);Effect of pronase P and glycosidase digestions on bioactivity of low molecular weight hepatopoitin[J];Chongqing Medicine;2007-09
6 LIU Xiao-juan,JANG Yong-mei,WANG Hong,et al.(Clinical Laboratory,West China Second Hospital,Sichuan University,Chengdu 610041,China);Initial research on measurement uncertainty of clinical biochemistry[J];Chongqing Medicine;2007-11
7 HE Ying,NIAN Zhi-guang,WANG Yi(Department of Medical Lab,Lingshui People's Hospital,Lingshui,Sichuan 638500,China);Found the indirect immunofluorescence of detecting immunoglobulin binding protein antibody with Hela cells[J];Chongqing Medicine;2008-03
8 WU Jun,ZHANG Guo-wei,HE Wei,et al.(Department of Dermatology,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China);Clinical study of arotinoid ethylester combined with narrow-band ultraviolet B in treating psoriasis vulgaris[J];Chongqing Medicine;2008-12
9 PENG Yu-sheng,HU Juan(1.Department of Clinical Laboratory,Yibin First People′s Hospital,Yibin 644000,China2.Department of Clinical Laboratory,General Hospital Chengdu Military Region,Chengdu 610083,China);Relationship between expression of VEGF and secretion of IL-1and IL-6 in human pituitary adenoma cells[J];Chongqing Medicine;2009-06
10 SHI Peng~(1),XU Zu-ming~(2),ZHANG Luo-man~(1*),CUI Jian-ying~(2),XU Fang~(2),SONG You-you~(2),WANG Su-li~(2),XU Lei~(2)((1. Department of) Health Statistics,Faculty of Health Services,Second Military Medical University,Shanghai 200433,China;(2.No.) 85 Hospital of PLA,Shanghai 200052);Application of factor analysis in analyzing management transformation in a Chinese hospital[J];Academic Journal of Second Military Medical University;2006-01
China Proceedings of conference Full-text Database 4 Hits
1 ;Preparation of Berberine Enzyme-controlled Colon-Specific tablets[A];[C];2008
2 ;Study on the reproducibility of organoleptic evaluation to the commercial specification of Rhizoma coptidis based on Delphi method[A];[C];2010
3 LIU Jun 1、2,ZHANG Jian-jun 2 (1. Guangzhou University of Chinese Medicine,Guangzhou 510405,China; 2.Guangdong Provincial Institute of Traditional Chinese Medicine,Guangzhou 510095,China);Optimization of the Processing Parameters for the Extraction of Total Glucoside of Paeony in Paeony Dispensing Granule using Box-Behnken experimental design[A];[C];2010
4 YU jingwei,LI yunhui,WANG kechao Computer science and technology department Harbin University Harbin ,P .R .China XIANG yang Traditional Chinese medicine hematology department The Chinese People's Liberation Army 210 hospital Dalian, P .R .China;Application of Factor analysis methods in the treatment diabetes of TCM literature research[A];[C];2010
【Co-references】
Chinese Journal Full-text Database 3 Hits
1 WU Ya zhou 1, ZHANG Yan qi 1, HUANG Ming hui 2, YANG Meng su 3, ZENG Zhi xiong 3, YI Dong 1 ( 1Department of Health Statistics, College of Preventive Medicine, Third Military Medical University, Chongqing 400038; 2Shenzhen Institute, City University of Hong Kong, Shenzhen 518057, China; 3Applied Research Center for Genomics Technology, City University of Hong Kong, Hong Kong);Normalization and analysis of expression data of gene chips[J];Acta Academiae Medicinae Militaris Tertiae;2004-07
2 He Xianmin,Wu Jianhu,He Jia.Department of health statistics,Second Military Medical University (200433),Shanghai;Identifying Differential Expression Genes in Small Sample Size with Parameter Statistical Methods[J];Chinese Journal of Health Statistics;2005-03
3 Jiang Dingfeng,Pan Juanjuan,Zhao Naiqing.Department of Biostatistics and Social Medicine,School of Public Health Fudan University(200032),Shanghai;Comparison of Methods Used for Detecting Differentially Expressed Genes[J];Chinese Journal of Health Statistics;2006-05
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 WU Yazhou1 ZHANG Ling2 GUO Botao1 WANG Wenchang1 YI Dong11 Department of Health Statistics,Military Preventive Medicine College,Third Military Medical University,Chongqing 400038;2 Department of Health and Medical Humanities Education,ThirdMilitary Medical University,Chongqing 400038;Application Research of Wavelet Multi-Scale in Gene Expression Chips[J];Beijing Biomedical Engineering;2009-03
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