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Expression of inflammatory media in acute lung injury induced by endotoxin in mice

QIN Kai-xiu,JIAN Hua-gang(Department of Emergency,Second Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing 400010,China)  
Objective To investigate the correlation between the two inflammatory media and their kinetic changes in endotoxin-induced acute lung injury.Methods The ALI model was set up by intraperineal injection of lipopolysaccharide(LPS).The changes of TNF-α,IL-8,IL-10 levels in the pulmonary tissues were detected by ELISA at different times.Besides,the following changes were observed: lung wet/dry weight ratio,lung histological manifestations.Results The levels of inflammatory media and W/D in ALI group were higher obviously than those in control mice,the expression of TNF-α was seen to peak at 4h and IL-8 at 2h,IL-10 at 8h in lung tissue after challenge.Conclusion Pro-inflammatory response and ant-inflammatory response occurred successively after injecting LPS,the unbalance between them may be the mechanism of LPS-induced acute lung injury.
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