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《Chongqing Medicine》 2007-13
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Expression and clinical significance of MMP-9,VEGF in renal cell carcinoma

ZHANG Yao,WU Xiao-hou,SUN Xiang-yu,et al.(1.Department of Urologic Surgery,People's Hospital of Suining City,Suining,Sichuan 629000,China;2.Department of Urology,First Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing 400016,China)  
Objective To study the expressions of matrix metalloproteinase-9(MMP-9),vascular endothelial growth factor(VEGF) and their correlation with angiogenesis and biological behaviour in renal cell carcinoma(RCC).Methods The expressions of MMP-9,VEGF and CD34 were detected by means of immunohistochemistry in 78 cases of RCC.Results The positive expression rate of MMP-9 was 87% in the high staging group and 50% in the low staging group,the statistical significance existed between the two groups(P0.01);the MVD was 140.86±24.87 in both positive expressions of MMP-9 and VEGF,was higher than that in the single positive ones(99.3±47.97)(P0.01)and the both negative ones(80.16±33.83)(P0.000 1).The expression of MMP-9 correlated with VEGF in renal cell carcinoma(r=0.409 66,P0.01).Conclusion MMP-9 and VEGF may serve as biological predictor for tumor metastatic potential in renal cell carcinoma.
【CateGory Index】: R737.11
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