Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chongqing Medicine》 2007-18
Add to Favorite Get Latest Update

Changes of TNF-α,IL-1β and cortisol in serum and hepatic GR following severe traumatic brain injury

QU Qiang,SHI Zhong△ (Department of Emergency,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China)  
Objective To observe the changes of TNF-α,IL-1β,ACTH,cortisol in serum and lymphocytic glucocorticoid resistant(GR) following severe traumatic brain injury(TBI).Methods The adult patients with severe TBI were randomly distributed to group Ⅰ(treated by ketamine and midazolam),group Ⅱ(no intervening) and group Ⅲ(normal contral).At 1h,2-4h,6-8h after TBI,ACTH,cytokine levels of TNF-α and IL-1β were measured by ELISA and radioimmuolgical assay(RIA),serum cortisol levels were determined,and total cytosolic GR in lymphocyte were detected with Western blotting.Results Serum ACTH,cortisol,TNF-α,IL-1β levels increased markedly,and there were two acmes in the observing curve.The lymphocytic GR was obviously down-regulated at protein levels after TBI,but only decreased more markedly in group Ⅱ than in group Ⅰ in Glasgow score 6-8 groups.Conclusion There is glucocorticoid resistant after severe TBI in human.There is inseparable relation of TNF-α and IL-1β.Ketamine and midazolam are apparently effective for reducing GR.
【Fund】: 国家重点基础研究发展计划资助项目(973-05 2005CB522605)。
【CateGory Index】: R651.15
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 2 Hits
1 LU Jian hua, DANG Jian, LI Hai di, GAO Jing sheng, XIONG Jia xiang (Department of Physiology, Third Military Medical University, Chongqing 400038, China);Effects of NMDA receptor on glucocorticoid receptor mRNA levels in hippocampus of rats after scald burn stress[J];Acta Academiae Medicinae Militaris Tertiae;2003-02
2 Shi Hanping,Li Jianzhen,Qin Luping,et al;Change of glucocorticoid receptor in hepatic and cerebral tissues and its role in hemorrhagic rats/[J];CHINESE CRITICAL CARE MEDICINE;1996-10
Chinese Journal Full-text Database 10 Hits
1 SHEN Hai ying, ZHOU Yuan guo, LU Jing li, et al. (Research Institute of Field Surgery,Daping Hospital, the Third Military Medical University, Chongqing 400042, China);The study of glucocorticoid efficiency difference between BALB/c and C57BL/6 mice[J];Chongqing Medical Journal;2003-06
2 WANG Jun ping, SU Yong ping, LIU Xian hua, ZHAO Jing hong, LIU Du hu, ZHOU Yan hong, QIN Rong (Institute of Combined Injuries, Third Military Medical University, Chongqing 400038, China);Expression of glucocorticoid receptor in the liver of severe scalded rats during the early stage of stress[J];Acta Academiae Medicine Militaris Tertiae;2002-08
3 LUO Donglin1 LIU Baohua1 ZHOU Jihong1 XIONG Renping1 LI Tao2 YE Xiufeng1 CHEN Jinping1. 1 Research Institute of Surgery, Daping Hospital, Third Military Medical University Chongqing 400042 2 Institute of Pathology, Chongging Medical University Chongging 400016;The role of glucocorticoid receptor in hepatic injury after trauma with hemorrhagic shock in rats[J];Journal of Endocrine Surgery;2007-03
4 QU Qiang~(1, 2), SHI Zhong~2, SU Yong-ping~(1), YIN Zhi-yong~3, XIAO Tao-yuan~4, AI Guo-ping~1, LU Jian-hua~1 (1.Institute of Combined Injure of PLA, the Third Military University, Chongqing 400038; 2. Emergency Department of Xinqiao Hospital; 3.Institute of Field Surgery;4. Central Laboratory);Establishment of Severe Traumatic Brain Closed Injury Animal Model in Non-anesthetic Mice[J];Sichuan Journal of Zoology;2005-01
5 DE-SHENG PAN*, WEI-GUO LIU#, XIAO-FENG YANG*,1, AND FEI CAO* *Department of Neurosurgery, The First Affiliated Hospital, Medical College of Zhejiang University, Hangzhou 310003, Zhejiang, China; #Department of Neurosurgery, The Second Affiliated Hospital, Medical College of Zhejiang University, Hangzhou 310009, Zhejiang, China;Inhibitory Effect of Progesterone on Inflammatory Factors After Experimental Traumatic Brain Injury[J];生物医学与环境科学(英文版);2007-05
6 LUO Dong-lin, ZHOU Ji-hong, LIU Bao-hua, HUANG Xian-kai, LIU Da-wei, XIONG Ren-ping, ZHANG Bo (Research Institute of Surgery, Daping Hospital, The Third Military Medical University, Chongqing 400042, China);Role of glucocorticoid receptor in hepatic injury in early stage after severe multiple injury[J];Chinese Journal of Pathophysiology;2003-01
7 HE Jia-yi*, WEI Jing-wang, ZHANG Jian-sheng. *Department of Neurosurgery, The Second Affiliated Hospital, Lanzhou University, Lanzhou Gansu 730030, China;Effect of Glucocorticosteroid on Plasma Levels of TNF-α and IL-1 β in Patients with Severe Traumstic Brain Injury[J];Chinese Journal of Clinical Neurosurgery;2007-01
8 LEI Peng ZHANG Xing-chao PENG Long-feng Department of Neurosurgery,General Hospital of Lanzhou Military Command,Lanzhou 730050, China;Effect of erythropoietineffects on protein expressions of IL-1βand S100βin rats with severe brain injury and hemorrhagic shock[J];Chinese Journal of Trauma;2007-09
9 LU Chuan, SUN Jun, CHEN Xiandong, et al. Wenzhou Second People's Hospital, Wenzhou 325000, China;Changes in levels of cerebrospinal fluid TNF- α、IL- 6 in patients with acute brain trauma[J];Zhejiang Journal of Traumatic Surgery;2008-03
10 LUO Donglin, ZHOU Jihong, LIU Baohua, XIONG Renping, YE Xiufeng, XU Xiang, CHEN Jinping. Research Institute of Surgery, Daping Hospital, The Third Military Medical University, Chongqing 400042, China;Changes in glucocorticoid receptor and heat shock protein 70 in liver tissue after trauma with hemorrhagic shock in rats[J];Chinese Critical Care Medicine;2005-11
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Shi Han-Ping,Xu Ren-Bao,Gao Han, Hua Ji-De,Shen Yan-Ming Dept.of General Surgery, Nan Fang Hospital, Guangzhou( 510515);A preliminary study on the mechanism of glucocorticoid depressing IL-1 activity[J];CHINESE JOURNAL OF PATHOPHYSIOLOGY;1995-05
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved