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《Chongqing Medicine》 2008-03
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Effects of matrine on proliferation and telomerase activity in human hepatocellular cell line HepG2

HE Song,ZUO Guo-qing,ZHANG Yan,et al.(1.Department of Gastroenterology,the Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China;2.Department of Pathophysiology,Chongqing Medical University,Chongqing 400016,China)  
Objective To investigate the anti-cancer mechanism of matrine by observing their effects on proliferation and telomerase activity.MethodsThe inhibition of proliferation in HepG2 cells were estimated by MTT-assay.Distribution of cells cycle and apoptosis were analysed using flow cytometry.The changes of telomerase activity were detected by PCR-ELISA method.ResultsMatrine could inhibit the proliferation of HepG2 cells,block cell cycle,induce apoptosis and inhibit the activity of telomerase.ConclusionThe inhibition of telomerase activity may be one of the mechanisms of the anti-cancer effect of matrine.
【CateGory Index】: R735.7
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【References】
Chinese Journal Full-text Database 2 Hits
1 HUANG Jin-fei JIA Jian-wen LUO Jian-jun WENG Qun-fang ZHONG Guo-hua Laboratory of Insect Toxicology,South China Agricultural University,Guangzhou 510642,China;Modes of Action of Six Different Botanical Alkaloids against Spodoptera litura Cultured Cell Line SL-1[J];Journal of Huazhong Agricultural University;2010-01
2 QIN Kunming,FANG Qianbo,CAI Hao,CAI Baochang (Jiangsu Key Laboratory of Chinese Medicine Processing,Nanjing University of Chinese Medicine,Nanjing 210029,China);Summary of Research on Anticancer Mechanism of Constituent Matrine[J];Journal of Shenzhen Polytechnic;2009-03
【Citations】
Chinese Journal Full-text Database 1 Hits
1 Tang Weixue,et alDepartment of Pathophys iology;DETERMINATION OF ANTICANCER DRUG SENSITIVITY TEST BY THE MTT COLO RIMETRIC ASSAY FOR HUMAN SOLID TUMORS[J];Journal of Chongqing Medical University;1992-02
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Zheng Xiujun, Deng Qan, Yang Chuanmin, et alDepartment of Pediatric Surgery, Affiliated Hospital of Qingdao Medical college, Qingdao 266003;CHEMOSENSITIVITY TEST FOR CHILDHOOD TUMORS BY MTT ASSAY[J];;1996-04
2 Tang Wer,et al (Dept of Urology,The College of Clinical Medicine .Chongqing University of Medical Sciences,Chongqing 400016);Guiding Postoperative Chemotherapy of Bladder Cancer With Drug Sensitivity Test of Autologous Tumor Cell[J];CHONGQING MEDICAL JOURNAL;1999-02
3 ZHANG Jun wen, DUAN Hong, TANG Wei xue, et al. (Department of gastroenterology,the First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400016,China);The interaction between 5-fluorouracil and Mitomycin C on human gastric carcinoma cell line(BGc-823)[J];Chongqing Medical Journal;2001-02
4 HE Song,SHEN Wei,SHEN Ding ming (Department of Gastroenterology,the Second College of Clinical Medicine, Chongqing University of Medical Sciences,Chongqing 400010,China);Taxol shows cytotoxic activity in hepatoma cell line hepG_2 in vitro[J];Chongqing Medical Journal;2003-03
5 YU Chang-lan,ZHANG Jun-wen(Department of Gastroenterology,First Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing 400016,China);Apoptosis of esophageal cancer inducing cell by arsenic trioxide and its influence on expression of C-myc and TGF-β_1[J];Chongqing Medicine;2006-11
6 CAO Jian, WU Fu (Department Of Pharmacy, Xinqiao Hospital, Third Military Medical University, Chongqing 400037,China);Effects of nordihydroguaiaretic acid treatment combined with Methotrexate or Vincristine on a human malignant glioma cell line[J];Acta Academiae Medicine Militaris Tertiae;2001-03
7 LI Hong yuan, CHE Yi, TANG Wei xue (Department of General Surgery, First Affiliated Hospital, Chongqing University of Medical Sciences , Chongqing 400016, China);Effects of curcumin on solid tumor and acute myeloid leukemic cells[J];Acta Academiae Medicinae Militaris Tertiae;2004-09
8 HE Song 1, ZUO Guo-qing 1, ZHANG Yan 1, TANG Wei-xue 2 ( 1Department of Gastroenterology, The Second Affiliated Hospital, Chongqing 400010; 2Department of Pathophysiology, Chongqing University of Medical Sciences, Chongqing 400016, China);Mechanism of supression on proliferation of human hepatoma cell line QGY by oxaliplatin[J];Acta Academiae Medicinae Militaris Tertiae;2005-12
9 DUAN Hong~1, ZHANG Jun-wen~2 (~1Department of Pathophysiology, ~2Department of Gastroenterology, The First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400016, China);Induction of apoptosis and influence of HIF-1α expression on esophageal carcinoma cell ECa109 by soybean isoflavone during hypoxia[J];Acta Academiae Medicinae Militaris Tertiae;2005-19
10 XIANG Zheng1, ZHANG Cai-quan1, TANG Wei-xue2 ( 1Department of General Surgery, The First Affiliated Hospital, Chongqing Key Laboratory of General Surgery, 2Department of Pathophysiology, Chongqing Medical University, Chongqing 400016, China );Mechanism of suppression on proliferation of human colon carcinoma cell line HT29 by oxaliplatin[J];Acta Academiae Medicinae Militaris Tertiae;2007-07
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 WANG Zhi-jie,HUANG Tie-niu,GUO Shu-fang,WANG Rui-hua (Virus Research Institute,Medical College of Wuhan University,Hubei Wuhan 430071,China);Effects of Emodin Extracted from Rhizoma Polygoni Cuspidati in Treating HSV-1 Cutaneous Infection in Guinea Pigs[J];Journal of Anhui Traditional Chinese Medical College;2003-04
2 ZHOU Lin, AI Zhong li, LIU Zhi su,et al Department of General Surgery of the Second Affiliated Hospital of Hubei Medical University, Wuhan 430071, P R China;An in vitro study of effect of Kushen compound preparation on human colon cancer cell line SW480[J];CHINESE JOURNAL OF CANCER;2000-04
3 LI Xu- fen1* , ZHANG Su- zhan1, ZHENG Shu2, ZHANG Xing2 1.Department of Oncology,the Second Affiliated Hospital School of Medicine, Zhejiang University,Hangzhou 310009,P.R.China 2.Cancer Institute,Zhejiang University, Hangzhou 310009, P.R.China;Effects of Matrine on hTERT- mRNA Expression and Telomerase Activity in K562 Cells[J];Chinese Journal of Cancer;2001-04
4 SI Wei ke*, GAO Li hong, LIU Bing, CHENG An, LI Peng, YAO JieDepartment of Clinical Biochemistry, the Third Military Medical University, Chongqing 400038, P.R.China;Regulation of G_1 Phase Cell Cycle Regulation Factors in Differentiation and Apoptosis of Matrine Induced Hepatoma Cells[J];Chinese Journal of Cancer;2001-08
5 Wo Xingde,Hong Xingqiu,Gao Chengxian,et al Molecular Medical Institution,Zhejiang College of TCM,Hangzhou(310009);Long-period Virulent Test of Curcumin[J];JOURNAL OF ZHEJIANG COLLEGE OF TCM;2000-01
6 Wan Xuying,Chen Zhe TCM Section,Changhai Hospital of Second Military Medical University,Shanghai (200433);Primary Liver Cancer Treated by Matrine Injection with TACE Operation[J];Journal of Zhejiang College of Tcm;2002-02
7 Wang Zhijie,Huang Tieniu,Liu Yanwen Medical College of Wuhan University,Wuhan(430071);Pharmadynamics Analysis to Emodin in Rhizoma Polygoin Cuspidati and Total Saponins in the Root of Astragalus Membranaceus Used on Anti Herpus Virus[J];Journal of Zhejiang College of Tcm;2003-01
8 REN Xin~1,YU Fang~1,YAN Jian-yi~2,ZHAO Dong-li~1 (Medical College of Dalian University,Dalian 116622,China);Analysis of alkaloid content in different organs in Sophora flavescens[J];Journal of Dalian University;2006-04
9 FENG Chen, TANG Suo-Qin, WANG Jian-Wen, LONG Hui, YANG Guang. Department of Pediatrics, People's Liberation Army General Hospital, Beijing 100853 , China;Matrine inhibits the proliferation of neuroblastoma LA-N-5 cell and MYCN mRNA expression[J];Chinese Journal of Contemporary Pediatrics;2008-02
10 SI Wei ke, XIAO Tao yuan, KANG Ge fei (Department of Clinical Laboratory Medicine, Third Military Medical University, Chongqing 400038, China);Effects of matrine on cell morphology and related factors of hepatocellular carcinoma cell HepG_2 in vitro[J];ACTA ACADEMIAE MEDICINE MILITARIS TERTIAE;2000-06
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Wang Ruixie et al Department of pathophysiology;EXPERIMENTAL STUDY ON MTT ASSAY USED I OR AlJNTICANCER DRUG SCREENNING[J];Journal of Chongqing Medical University;1991-04
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