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《Chongqing Medicine》 2008-03
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Effects of matrine on proliferation and telomerase activity in human hepatocellular cell line HepG2

HE Song,ZUO Guo-qing,ZHANG Yan,et al.(1.Department of Gastroenterology,the Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China;2.Department of Pathophysiology,Chongqing Medical University,Chongqing 400016,China)  
Objective To investigate the anti-cancer mechanism of matrine by observing their effects on proliferation and telomerase activity.MethodsThe inhibition of proliferation in HepG2 cells were estimated by MTT-assay.Distribution of cells cycle and apoptosis were analysed using flow cytometry.The changes of telomerase activity were detected by PCR-ELISA method.ResultsMatrine could inhibit the proliferation of HepG2 cells,block cell cycle,induce apoptosis and inhibit the activity of telomerase.ConclusionThe inhibition of telomerase activity may be one of the mechanisms of the anti-cancer effect of matrine.
【CateGory Index】: R735.7
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