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《Chongqing Medicine》 2009-05
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Impact of probiotics on anti-Helicobacter pylori therapy

LIU Zhi-peng,ZHOU Li-quan,YOU Bing,et al.(The 324th Hospital of PLA,Chongqing 400020,China)  
Objective To observe the eradication rate and side-effect of probiotics supplementation on anti-Helicobacter pylori triple therapy.Methods The 200 patients with peptic ulcer or chronic gastritis,in whom the results were both positive for the 14C-urea breath test and the rapid urease test,were divided into two groups randomly,i.e,group A was assigned to 14d triple therapy consisting of esomeprazole,clarithromycin and amoxicillin,group B was assigned to 14d triple therapy plus Medilac-S(Bacillus subtilis,Streptococcus faecium).The side-effects questionnaire was filled in once a week.The effect on eradication of Helicobacter pylori was determined by the 14C-urea breath test and the rapid urease test again four weeks later after finishing cure.Results The eradication rate of both groups was approximate,92.30% and 93.88%,respectively(P0.05).The gastrointestinal side-effects were obviously fewer in group B than that in group A(P0.01).Conclution Medilac-S supplementation may cut down gastrointestinal side-effects related to anti-Helicobacter pylori triple therapy,and shows a significant improvement in treatment tolerability.
【CateGory Index】: R573
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1 GONG Fang-hong,HE Song,ZHANG De-chun,GUO Ya-nan(Department of Pathogenic Biology,Molecular Medicine & Tumor Research Center,Chongqing Medical University,Chongqing 400016,China);Effect of probiotics on Helicobacter pylori eradication and adverse events during eradication therapy in China:a meta analysis[J];Chinese Journal of Microecology;2009-09
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