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《Chongqing Medicine》 2009-22
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Study of effect of enriched environmental inteference on neurons in hippocampus of HIBD neonatal rats

YU Ruo-gu,LI Gang,ZHONG Xiao-yun,et al.(Chongqing Maternal and Child Health Institute,Chongqing 400013,China)  
Objective To explore the possible mechanism of the recovery of hypoxic-ischemic brain damage(HIBD) and the reconstruction of the brain nervous net with early envinonmental inteference.Methods The Sprague-Dawley(SD) rat′s models of HIBD were established by the method of Rice.Then the rats were divided into 3 groups at random:normal control group,hypoxic-ischemic(HI) group and enriched environment(EE) group.The early touch and enriched environment interference were administrated to the rats since 2d after HIBD.On 28d,Morris water maze was used to evaluate the learning and memory ability,also the weight of rats were measured.The HE stain and the Nissl stain were respectively employed to observe the morphopathologic changes and the number of live neurons in the left-sided hippocampus of the rats.Results The water maze scores of EE group in place navigation test and spatial probe test were much higher than that of HI group(P0.001),there was no significant difference compared EE group with the normal control group(P0.05).The weight of EE group was much higher than that of HI group(P0.01),there was no significant difference compared EE group with normal control group(P0.05).HE stain displayed that the left-sided hippocampus of EE group was minimal abnormal with the slightly disorganized neurons and some cells lost;while the morphology of HI group was obviously abnormal with reduced cell layers;the morphology of normal control group was normal.The Nissl stain showed that the number of live neurons in the left-sided hippocampus of EE group was much more than that of HI group(P0.01).There was no significant difference compared EE group with normal control group(P0.05).Conclusion(1)The decreased neuron damage in the injured side brain tissue of HIBD neonatal rats implies that the enriched environment could protect both the neuron and the axon.(2)The neonatal rats with HIBD have disturbance with the ability of long-term learning and memory,while the enriched environmental inteference can markedly improve this ability,which indicates that early environmental inteference has great benefit to the protection of long-term learning and memory.
【CateGory Index】: R722.1
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 LIU Xiao-rong,ZHAO Cong-min,ZHANG Yu-ping(Department of Pediatrics,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China);Effect of hydrotherapy on learning and memory abilities of neonatal rats with hypoxia-ischemia brain damage[J];Chongqing Medicine;2006-20
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Jia Huijuan1 Li Yuan1 Wu Juanjuan1 Zhang Anmin2(1.School of Phydical Education,Shanxi University,Taiyuan Shanxi 030006;2.School of Physical Education,Shanxi University of Finance and Economics,Taiyuan Shanxi 030006);Exercise and the Hippocampal cAMP Research[J];Sport Forum;2010-01
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6 TANG Wei1,PENG Kang2,YANG Zhen-hui2,DIAO Jian-xin2,ZHU Chuan-wu1,LEI Xiao-lin3 1Medical College of Jishou University,Jishou 416000,China;2College of Traditional Chinese Medicine,Southern Medical University,Guangzhou 510515,China;3Orient Pharmaceutical Limited Company,Guangzhou 510515,China;Molecular mechanism of Wulongdan for improving the learning and memory abilities of rats with chronic cerebral ischemia[J];Journal of Southern Medical University;2010-10
7 Lü Pei-yuan~1,YIN Yu~1,MA Hong-jun~2,WANG Wei-bin~1,LIANG Cui-ping~1,LI Wen-bin~(3*)(1 Department of Neurology,Hebei Provincial People's Hospital,Shijiazhuang Hebei 050051;2 Electron Microscopy Center,Hebei Medical University,3 Department of Pathophysiology,Shijiazhuang Hebei 050017,China);Ultrastructural pathologic features of neuron of hippocampus in the mice with vascular dementia[J];Journal of Chinese Electron Microscopy Society;2004-05
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1 ZHANG Ri-hui LIU Yu HAN Zhong-yuan (Department of Sports Physiology and Biochemistry,Shenyang Sport University,Shenyang 110102);Influence of Fatigue by Training on Memory and Hippocampus Glutamate in the Rat[A];[C];2007
2 LI Hao,YAO Ming-jiang~*,XU Li,LIU Jian-gang,ZHAO Wen-ming (Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091 China);Effects of Huannao Yicong Decoction on Cognitive Function and Expression of Bcl-2 and Bax Protein of Hippocampus in Cognitive Impairment Rats[A];[C];2009
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