Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chongqing Medicine》 2010-12
Add to Favorite Get Latest Update

Clinic pathological study of metastasis-associated protein1 (MTA1),Matrix Metalloproteinase-9(MMP-9) expression in breast cancer

LI Bin1,CHEN Wu-ke2,CHEN Peng3,et al.(1.Department of Tumor,Affiliated Hospital of Xi′an Medical College,Xi′an 710077,China;2.Department of Tumor Surgery,First Affiliated Hospital of Xi′an Traffic University,Xi′an 710061,China;3.Department of Biochemistry,Xi′an Medical College,Xi′an 710021,China)  
Objective To investigate the relationship between the expression of MTA1,MMP-9 protein and lymph node metastasis in breast cancer.The relationships between the expressions of MTA1,MMP-9 protein and the clinical parameters of breast carcinoma were analyzed.To initiatory explore the relationship between MTA1,MMP-9 protein.Methods SP immunohistochemical technique was used to detect the expressions of MTAI and MMP-9 protein among the 45 human breast cancer samples.Results The positive rates of MTA1,MMP-9 protein were 71.0%,64.0% respectively.Analysis of MTA1 over-expression indicated there hadn′t relationships between age,tumor size,ER,PR and c-erb-B2 and MTA1.But MTA1 was significantly correlated with lymphatic metastasis(P0.05).MMP-9 over-expression was significantly correlated with lymphatic metastasis(P0.05) and was inversely correlated with PR(P0.05).There had not relationships between MMP-9 and age,tumor size,ER and c-erb-B2.The co-expression of MTAI and MMP-9 was significantly correlated with lymphatic metastasis(P0.05).Conclusion The over-expression of MTA1 stimulates the lymph node metastasis of breast cancer and the orientation variety of MTA1 protein is related to the metastasis of breast cancer.The over-expression of MMP-9 stimulates the metastasis of lymph node of breast cancer and a negative correlation was found between MMP-9 and PR.The co-expression of MTAI and MMP-9 was the biological character of breast cancer high aggressiveness.
【CateGory Index】: R737.9
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 2 Hits
1 ZHANG Yao,WU Xiao-hou,SUN Xiang-yu,et al.(1.Department of Urologic Surgery,People's Hospital of Suining City,Suining,Sichuan 629000,China;2.Department of Urology,First Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing 400016,China);Expression and clinical significance of MMP-9,VEGF in renal cell carcinoma[J];Chongqing Medicine;2007-13
2 LI Meng-quan,LI Jing-ruo,BAO Jun-tao,SU Jing,LI Jian-zhang(The First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052,R.P.China);Expression of MTA1 pretein in breast cancer and its significance[J];Shandong Medical Journal;2007-15
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LIU Zhi-cai * ,GUAN Fu-shun,GUO Jian-zhuang,CUI Wen-tao,WANG Zhen-hai,WANG Fu-qiang Department of Thoracic Surgery ,Tum or Hospital,Linzhou 456550,P.R.China;Relationship between Carcinoma Cell Embolus of Esophageal or Cardic Cancer and Its Clinical Pat hology[J];Chinese Journal of Cancer;2002-05
2 Ye-zhong Wang, Xin-yu Peng, Qi-wu Xu,Qi Liu, Feng Li, Hong-an Li Department of Neurosurgy, First Affiliated Hospital of Shihezi University, Shihezi 832008, P.R.China Department of Neurosurgy, Huashan Hospital, Fudan University, Shanghai 200040, P.R.China Department of Pathology, First Affiliated Hospital of Shihezi University, Shihezi 832008, P.R.China;Expression and Clinical Significance of uPA and VEGF in Meningiomas,Gliomas and Metastatic Brain Tumors[J];Chinese Journal of Neuro-Oncology;2005-01
3 ZENG Jian-hua1,ZHONG Ling1,XU Bo2(1Department of Obstetrics and Gynecology,The Second Affiliated Hospital,Chongqing Medical University,Chongqing 400010;2Department of Obstetrics and Gynecology,Shenzhen Women and Children's Hospital,Shenzhen 518028,China);Dexamethasone inhibits cervical carcinoma cell xenografted tumors in nude mice[J];Acta Academiae Medicinae Militaris Tertiae;2008-13
4 QIN Zhen1,LUO Bin2,WANG Xu-dong3(1Department of Respiratory Diseases,3Department of Pathology,Ninth People's Hospital of Chongqing City,Chongqing 400700;2Faculty of Clinical Medicine,Chongqing Medical and Pharmaceutical College,Chongqing 400051,China);Relationship of matrix metalloproteinase-9 expression and angiogenesis in lung carcinoma and its significance[J];Acta Academiae Medicinae Militaris Tertiae;2009-07
5 DONG Ji-Min 1, HU Xiao-Rong 2, SUN Ai-Xiong 3,HE Ji-Yin 4, LI Xiu-Xia 4 1Department of Geriatrics, Xi'an Centric Hospital, Xi'an 710003, China, 2Department of Obstetrics & Gynecology, Hospital of Workers & Staffs of Yanan Cigarette Factory, Yanan 716000, China, 3Family Planning Instructory Station of Zichang County, Zichang 717300, China, 4Department of Respiratory Medicine,Second Hospital, Medical College,Xi'an Jiaotong University, Xi'an 710003, China;Thrombospondin-1, microvessel density in primary non-small cell lung cancer and their clinical relevance[J];Journal of The Fourth Military Medical University;2004-24
6 CHEN Shao\|qin\+1, XU Dong\|po\+1, DAI Qi\|bao\+1, YE Jian\|xin\+1, QU Li\|juan\+2 (1.Department of Oncology, The Affiliated First Hospital, Fujian Medical University, Fuzhou\ 350005, China 2.Department of Pathology, Fujian General Hospital of Nanjing Millitary Region, Fuzhou\ 350025, China) \ \;Expression of Transforming Growth Factor β_1 in Colorectal Carcinoma and Synchronous Metastatic Liver Tumor[J];Journal of Fujian Medical University;2003-01
7 DU Pang,WEI Jingguo.Department of Radiology,Tangdu Hospital of the Fourth Military Medical University,Xi′an 710038;The relationship between the expression of VEGF and VEGFR and biological characteristics of liver cancer[J];Radiologic Practice;2002-06
8 WANG Ying, WANG Xiao xi, SHEN Bin hong, et al (No. 411 Hospital of PLA, Shanghai 200081, China);The Effect of Endostatin Transfected Bifdobacterium Oral Powder Preparation (ETB-2) on Human Gastric Carcinoma[J];Journal of Navy Medicine;2002-02
9 QIU Min-mei,YI Shi-jian,ZHONG De-wu,et al (Department of Surgery,Fuyong People's Hospital,Shenzhen,Guangdong 518103,China);Expression of KAI-1 in Hepatocellular Carcinoma and the Relationship Between the Expression and Clinical Pathological Characterization[J];Journal of Nanhua University(Medical Edition);2008-05
10 WANG Ying, WANG Xiao-xi, SHEN Bin-hong, NI Hai-dong, DING Ai-ni (Pathology Department, PLA 411th Hospital, Shanghai 200081, China);Study on Correlation between Microvessel Density andProliferating Cell Nuclear Antigen in Advanced Gastric Cacinoma[J];Journal of Clinical Medical officer;2001-02
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 LI Xiao chuan,WANG Yan qing (1.Department of General Surgery,Municipal Hospital of Qingdao,Shandong Provice,Qingdao 266011,China;2.Dpeartment of General Surgery,the First Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing 400016,China);Expression of MMp_2、MMP_9 and PCNA in colorectal tumors and its clinical implication[J];Chongqing Medical Journal;2003-07
2 WT5”BX] LIN Chuan, CHEN Han, WU Mengchao, et al.Eastern Hepatobilliary Surgery Hospital, Second Military Medical University Shanghai 200438, China. [WT5”HZ];Expression of tumor metastasis gene MTA 1 in hepatocellular carcinoma: clinical implications[J];Chiese Journal of Surgery;2000-12
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved