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《Chongqing Medicine》 2010-12
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Clinic pathological study of metastasis-associated protein1 (MTA1),Matrix Metalloproteinase-9(MMP-9) expression in breast cancer

LI Bin1,CHEN Wu-ke2,CHEN Peng3,et al.(1.Department of Tumor,Affiliated Hospital of Xi′an Medical College,Xi′an 710077,China;2.Department of Tumor Surgery,First Affiliated Hospital of Xi′an Traffic University,Xi′an 710061,China;3.Department of Biochemistry,Xi′an Medical College,Xi′an 710021,China)  
Objective To investigate the relationship between the expression of MTA1,MMP-9 protein and lymph node metastasis in breast cancer.The relationships between the expressions of MTA1,MMP-9 protein and the clinical parameters of breast carcinoma were analyzed.To initiatory explore the relationship between MTA1,MMP-9 protein.Methods SP immunohistochemical technique was used to detect the expressions of MTAI and MMP-9 protein among the 45 human breast cancer samples.Results The positive rates of MTA1,MMP-9 protein were 71.0%,64.0% respectively.Analysis of MTA1 over-expression indicated there hadn′t relationships between age,tumor size,ER,PR and c-erb-B2 and MTA1.But MTA1 was significantly correlated with lymphatic metastasis(P0.05).MMP-9 over-expression was significantly correlated with lymphatic metastasis(P0.05) and was inversely correlated with PR(P0.05).There had not relationships between MMP-9 and age,tumor size,ER and c-erb-B2.The co-expression of MTAI and MMP-9 was significantly correlated with lymphatic metastasis(P0.05).Conclusion The over-expression of MTA1 stimulates the lymph node metastasis of breast cancer and the orientation variety of MTA1 protein is related to the metastasis of breast cancer.The over-expression of MMP-9 stimulates the metastasis of lymph node of breast cancer and a negative correlation was found between MMP-9 and PR.The co-expression of MTAI and MMP-9 was the biological character of breast cancer high aggressiveness.
【CateGory Index】: R737.9
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