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《Chongqing Medicine》 2010-17
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Correlation of ERK signal transduction pathway with MMP-9 expression in lung adenocarcinoma

LI Lian1,LI Ming2,ZHOU Xiang-dong3(1.Department of Respiratory Medicine,Jiangjin District People′s Hospital,Jiangjin,Chongqing 402260,China;2.Department of Pathology,Jiangjin District People′s Hospital,Jiangjin,Chongqing 402260,China;3.Department of Respiratory Medicine,Second Affiliated Hospital,Chongqing Medical University,Chongqing 400010,China)  
Objective To investigate the correlation of extracelluar signal-regulated kinase(ERK) with matrix metalloproteinase-9(MMP-9)and its significance in lung adenocarcinoma.Methods SP immunohistochemistry was used to test the expression of pERK and MMP-9 in 67 specimens of lung adenocarcinoma.Western blot was used to detect the protein levels of MMP-9 in lung adenocarcinoma SPC-A-1 cells after blocking ERK signal transduction pathway by PD98059.The correlation of pERK and MMP-9 expression was also analyzed.Results The high expression rate of pERK proteins was higher in lung adenocarcinoma tissues than in the normal tissues(65.6%vs 14.3%).The high expression rate of MMP-9 protein was higher in lung adenocarcinoma tissues than in the normal tissues(73.1%vs 21.4%).The high expression rate of pERK was positively correlated to the high expression rate of MMP-9(r=0.57,P0.05).The high expression rate of pERK was correlated to lymph node metastasis and TNM stage(P0.05),but not to patients,age and tumor size(P0.05).The high expression rate of MMP-9 was correlated to lymph node metastasis and TNM stage(P0.05),but not to patient′s age and tumor size(P0.05).PD98059 concentration-dependently inhibited ERK pathway and reduced MMP-9 protein expression.Conclusion ERK signal transduction pathway might promote lung adenocarcinoma progression by up-regulating MMP-9 expression,and might be an important route in invasion and metastasis of lung adenocarcinoma.
【Fund】: 重庆市卫生局2009年度医学科研计划资助项目(2009-2-429)
【CateGory Index】: R734.2
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【Citations】
Chinese Journal Full-text Database 3 Hits
1 Lian Li,1 Tong-Hua Mei,1 Xiang-Dong Zhou1 and Xin-Gao2 Zhang1. Department of Respiratory Medicine, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400010, P. R. China 2. Department of Respiratory Medicine, Zigong First People's Hospital, Zigong, Sichuan, 643000, P. R. China;Expression and clinical significance of matrix metalloproteinase (MMP)-26 protein in non-small cell lung cancer[J];Chinese Journal of Cancer;2009-01
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3 KONG Ling-Ling,WANG Xue-Chun,CUI Wen,WANG Xu,YANG Qing-Yuan,SONG Xi-Yuan,JIANG Xiao-Gang,YAN Chun-Yan Department of Pathology,Jining Medical College,Jining 272013,China;Expression of MMP-9 and its clinical significance in cervical squamous carcinoma[J];Journal of the Fourth Military Medical University;2008-03
【Co-citations】
Chinese Journal Full-text Database 4 Hits
1 QIN Zhen1,LUO Bin2,WANG Xu-dong3(1Department of Respiratory Diseases,3Department of Pathology,Ninth People's Hospital of Chongqing City,Chongqing 400700;2Faculty of Clinical Medicine,Chongqing Medical and Pharmaceutical College,Chongqing 400051,China);Relationship of matrix metalloproteinase-9 expression and angiogenesis in lung carcinoma and its significance[J];Acta Academiae Medicinae Militaris Tertiae;2009-07
2 LI Bin1,CHEN Wu-ke2,CHEN Peng3,et al.(1.Department of Tumor,Affiliated Hospital of Xi′an Medical College,Xi′an 710077,China;2.Department of Tumor Surgery,First Affiliated Hospital of Xi′an Traffic University,Xi′an 710061,China;3.Department of Biochemistry,Xi′an Medical College,Xi′an 710021,China);Clinic pathological study of metastasis-associated protein1 (MTA1),Matrix Metalloproteinase-9(MMP-9) expression in breast cancer[J];Chongqing Medicine;2010-12
3 ZHU Feng1,ZHANG Yan2,ZHANG Hui-qing1,ZHANG Ying-jie1(1.Department of Urology,the First Affiliated Hospital of Xinxiang Medical University,Weihui 453100;2.Function Laboratory,Science and Technology Agency of Xinxiang Medical University,Xinxiang 453001,China);Correlations of matrix metalloproteinase content with invasion and metastasis of the transitional cell carcinoma of bladder[J];Journal of Modern Urology;2009-06
4 JIANG Cui-ping,et al (Department of Urology,the First Affiliated Hospital,Chongqing Medical University);The differential expression of VEGF165b in the renal cell carcinoma and normal renal tissues and its clinical significance[J];Journal of Chongqing Medical University;2009-03
【Secondary Citations】
Chinese Journal Full-text Database 5 Hits
1 CHEN Xiang-Li1, ZHANG Wang-Gang1, CHEN Xiao-Yan2, SUN Zhong-Min2, LIU Su-Hu1 1. Department of Hematology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, P. R. China 2. Department of Respiratory Medicine, The First Affiliated Hospital, Xi' an Jiaotong University, Xi'an, Shaanxi, 710061, P. R. China;Correlations of S100A4 Protein Expression to Invasion and Metastasis of Non-small Cell Lung Cancer[J];Chinese Journal of Cancer;2006-09
2 LU Zhong-Qiang1, WANG Yi-Min2, CAO Yan-Yan2, ZHANG Qing-Jun3, ZHANG Xiang-Hong4, LI Yue-Hong4, WANG Heng-Shu4, XIE Hui-Ling1, JIAO Bao-Hua1, ZHANG Jian-Hui2 1. Department of Neurosurgery, The Second Affiliated Hospital, Hebei Medical University, Shijiazhuang, Hebei, 050000, P. R. China 2. Laboratory of Molecular Biology, Hebei Provincial Cancer Institute, Hebei Medical University, Shijiazhuang, Hebei, 050011, P. R. China 3. Department of Neurosurgery, People's Hospital, Peking University, Beijing, 100044, P. R. China 4. Department of Pathology, The Second Affiliated Hospital, Hebei Medical University, Shijiazhuang, Hebei, 050000, P. R. China;Correlations of Polymorphisms in Matrix Metalloproteinase-3 and -7 Promoters to Susceptibility to Brain Astrocytoma[J];Chinese Journal of Cancer;2007-05
3 WENG Mi-Xia1, WU Cui-Huan2, YANG Xiu-Ping1 1. Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, P. R. China 2. Department of Pathology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, P. R. China;Expression and Significance of E-cadherin, CD44v6, and Proliferating Cell Nuclear Antigen in Non-small Cell Lung Cancer[J];Chinese Journal of Cancer;2008-02
4 LI Xiao chuan,WANG Yan qing (1.Department of General Surgery,Municipal Hospital of Qingdao,Shandong Provice,Qingdao 266011,China;2.Dpeartment of General Surgery,the First Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing 400016,China);Expression of MMp_2、MMP_9 and PCNA in colorectal tumors and its clinical implication[J];Chongqing Medical Journal;2003-07
5 WU Xiao-Qiu1,2), LI Yu-Xia2), FU Ya-Yuan2), LI Dian-Jun1), SANG Qing-Xiang3), WANG Yan-Ling2)**(1)Department of Immunology, Harbin Medical University, Harbin 150086, China; 2)State Key Laboratory of Reproductive Biology, Institute of Zoology, The Chinese Academy of Sciences, Beijing 100080, China;3)Department of Chemistry and Biochemistry and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA);Effect of Matrix Metalloproteinase-26 on Cell Invasiveness in Human Choriocarcinomal Cell Line JEG-3[J];Progress in Biochemistry and Biophysics;2006-06
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