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《Chongqing Medicine》 2010-18
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Effects of trans-resveratrol on expression of iNOS mRNA after injury in rats hippocampus by Aβ_(25-35)

WANG Shun-wang1,2,XU Ping1,LIU Hai-Jun1,et al.(1.Affilited Hospital,Zunyi Medical College,Zunyi,Guizhou 563003,China;2.Department of Neurology,Third Hospital of Xiamen,Xiamen,Fujian 361100,China;3.School of Pharmacy,Fudan University,Shanghai 200433,China)  
Objective To observate the effects of ingredient of polygonum cuspidatum trans-resveratrol(TR) on expression of iNOS mRNA with bilateral hippocampal injection of Aβ25-35 in vivo modeling method.Methods After being trained using Morris water maze(MWM),rats were randomly divided into 5 groups:(1) sham-operated group;(2) model group:injecting Aβ25-35 to hippocampus;(3)-(5) were TR high,middle and low dose group:these three groups were treated with TR after the model establishment.Molding later TR was intervened to protect the dementia rats,in order to achieve the effect of delaying or avoiding dementia.Using real-time RT-PCR to detect the mRNA expression of inducible nitric oxide synthase(iNOS) in hippocampus and cortex.Results Escape latency of model group was significantly longer than that of TR high,medium,low-dose group and sham-operated group in MWM.The mRNA expression of iNOS in each group was 0.23 ± 0.90,1.23 ± 0.91,0.34 ± 0.18,0.48 ± 0.12,0.87±0.49.TUNEL method to detect the percentage of apoptotic cells in hippocampus between the five groups,respectively:(the first 11 d)(3.23±0.52)%,(21.32±5.02)%,(5.72±1.56)%,(7.21±1.22)%,(10.93±3.25)%;(the first 17 d)(3.21±0.29)%,(16.31±4.27)%,(5.13±2.00)%,(7.12±1.78)%,(9.84±2.66)%.The percentage of apoptotic cells among the each group was statistically different(P0.01).Conclusion Treatment with different dose of TR can reduce Aβ25-35-induced memory impairment in rats.The mechanism may be partly associated with downregulating the mRNA expression of iNOS in hippocampus,and reducing the cell apoptosis in hippocampus.
【CateGory Index】: R285.5
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