Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chongqing Medicine》 2010-18
Add to Favorite Get Latest Update

Effects of trans-resveratrol on expression of iNOS mRNA after injury in rats hippocampus by Aβ_(25-35)

WANG Shun-wang1,2,XU Ping1,LIU Hai-Jun1,et al.(1.Affilited Hospital,Zunyi Medical College,Zunyi,Guizhou 563003,China;2.Department of Neurology,Third Hospital of Xiamen,Xiamen,Fujian 361100,China;3.School of Pharmacy,Fudan University,Shanghai 200433,China)  
Objective To observate the effects of ingredient of polygonum cuspidatum trans-resveratrol(TR) on expression of iNOS mRNA with bilateral hippocampal injection of Aβ25-35 in vivo modeling method.Methods After being trained using Morris water maze(MWM),rats were randomly divided into 5 groups:(1) sham-operated group;(2) model group:injecting Aβ25-35 to hippocampus;(3)-(5) were TR high,middle and low dose group:these three groups were treated with TR after the model establishment.Molding later TR was intervened to protect the dementia rats,in order to achieve the effect of delaying or avoiding dementia.Using real-time RT-PCR to detect the mRNA expression of inducible nitric oxide synthase(iNOS) in hippocampus and cortex.Results Escape latency of model group was significantly longer than that of TR high,medium,low-dose group and sham-operated group in MWM.The mRNA expression of iNOS in each group was 0.23 ± 0.90,1.23 ± 0.91,0.34 ± 0.18,0.48 ± 0.12,0.87±0.49.TUNEL method to detect the percentage of apoptotic cells in hippocampus between the five groups,respectively:(the first 11 d)(3.23±0.52)%,(21.32±5.02)%,(5.72±1.56)%,(7.21±1.22)%,(10.93±3.25)%;(the first 17 d)(3.21±0.29)%,(16.31±4.27)%,(5.13±2.00)%,(7.12±1.78)%,(9.84±2.66)%.The percentage of apoptotic cells among the each group was statistically different(P0.01).Conclusion Treatment with different dose of TR can reduce Aβ25-35-induced memory impairment in rats.The mechanism may be partly associated with downregulating the mRNA expression of iNOS in hippocampus,and reducing the cell apoptosis in hippocampus.
【CateGory Index】: R285.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 7 Hits
1 SONG Chao-yan1,CUI Jian-zhong2,HONG Jun2,WANG Chun-sheng1(1.Department of Neurosurgery,The First Hospital of Baoding,Baoding Hebei 071000;2.Department of Neurosurgery,Gongren Hospital of Tangshan,Tangshan Hebei 063000,China);Study on the effect of nitric oxide synthase on the learning and memorizing ability of rats after traumatic brain injury[J];Journal of Bengbu Medical College;2009-07
2 FANG Fang ,YAN Yong ,FENG Zhan-hui ,et al. (Department of Neurology ,First Affaliated Hospital,Chongqing University of Medical Sciences,Key Laboratory of Neurology in Chongqing ,Chongqing 400016,China);Study of Alzheimier's disease animal model induced by multiple factors[J];Chongqing Medicine;2007-02
3 GONG Qi-hai1,2,WANG Qian1,SHI Jing-shan1,2,XIE Xiao-long1,HUANG Bin1,WU Qin2,HUANG Xie-nan1(1.Department of Pharmacology,Zunyi Medical College,Zunyi 563000, China;2.Key Laboratory of Basic Pharmacology of Guizhou Province,Zunyi 563000,China);Protective effects of resveratrol on injury induced by oxygen-glucose deprivation in the primary cultured cortical neurons of neonatal rats[J];West China Journal of Pharmaceutical Sciences;2007-05
4 CHEN Yan, WANG Guang-nan, GUO Fu-xiang, et al.Department of Anesthesia,205 Hospital of PLA, Jinzhou 121000, China;Effects of Pioglitazone on LPS-induced Hippocampal Damages and iNOS and IL-1β Expression in Rats[J];Chinese General Practice;2008-21
5 LUO Su Fang, JIN Xing Zhong, YE Jian Feng, ZHANG Pei Wen (Department of Toxicology, First Military Medical University, Guangzhou 510515);Advances in research on 3,4′,5 trihydrostilbene 3 [WTHX]β D glucoside, an effective component from Polygonum cuspidatum Sieb. et Zucc[J];CHINESE JOURNAL OF PHARMACOLOGY AND TOXICOLOGY;1999-01
6 ZHOU Mao-jin~2,CHEN Xiao-yan~1,ZHONG Da-fang~(1)(1.Shanghai Institute of Materia Medica,Chinese Academy of Science,Shanghai 201203,China;2.Shenyang Pharmaceutical University,Shenyang 110016,China);Metabolism of trans-resveratrol-3-O-glucoside in vitro in rat tissues[J];Acta Pharmaceutica Sinica;2007-05
7 ZHANG Pei-Wen, YU Chuan-Lin, WANG Yao-Zhong,LUO Su-Fang, SUN Lie-Sha, LI Rui-Song(Department of Pharmacology, First Military Medical University, Guangzhou 510515, China);Influence of 3,4' ,5-trihydroxystibene-3-β-mono-D-glucoside on vascular endothelial epoprostenol and platelet aggregation[J];中国药理学报(英文版);1995-03
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 YAO Chun-yan,LIU Wen-zhe~* (College of Life Sciences,Northwest University,Xian 710069,China);Seasonal Change of Anthraquinone in Vegetative Organs of Polygonum cuspidatum[J];Acta Botanica Boreali-occidentalia Sinica;2005-01
2 Tang Yuenian 1, Li Fang 1, Lin Jianhai 2, Li Xiaohong 2 ( 1Department of Pharmacy, 2Department of Internal Medicine, Xinhua Hospital, Shanghai Second Medical University, Shanghai 200092, China);Correlation on the drugs concentration of the polydatin and systolic pulmonary artery pressure in hypoxic young pigs[J];Chinese Journal of Clinical Pharmacy;2003-02
3 ZHANG Jie1 LONG Yinf1 HU Xiqi1 CAO Ping1 ZHRENG Yaofan1 LI Xianhui2(1.Medicine Department,clinical,class 1 grade 2006 of Jishou University,Jishou Hunan,416000,China;2 Department of Physiology of Jishou University Medicine Department,Jishou Hunan,416000,China);Advances and evaluation on research of Animal model of Alzheimer's disease[J];Chinese Journal of Ethnomedicine and Ethnopharmacy;2009-10
4 YANG Li,WANG Xing,XIN Xiu,WANG Min-zhi(School of Life Science and Engineering,Southwest Jiaotong University,Chengdu,610031,China);The Determination Method Research of Gastrodin in Liver and Kidney of Rats[J];Lishizhen Medicine and Materia Medica Research;2011-02
5 CHEN Peng,YANG Li-chuan,LEI Wei-ya,SHEN Zhi-qiang*(Yunnan Pharmacological Laboratories of Natural Products,Kunming Medical College,Kunming 650031,China);Effects of Polydatin on Platelet Aggregation and Platelet Cytosolic Calcium[J];Natural Product Research and Development;2005-01
6 WANG Kai-jin,ZHANG Ying-jun*,YANG Chong-ren (State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650204,China);Recent Advance on the Chemistry and Bioactivity of Genus Polygonum[J];Natural Product Research and Development;2006-01
7 Guo Zan,Yang Jing,Xu Peng,Gao Lu,Yuan Fang,Zhang Yi(Hebei Medical University,Shijiazhuang 050017,Hebei,China);Study on Polydatin inhibiting carotid sinus baroreflex in anesthetized rats[J];Modern Journal of Integrated Traditional Chinese and Western Medicine;2011-13
8 LIN Jian-hai 1,LI Xiao-hong 1,TANG Yue-nian 1 and RAN Hong-feng 2 (1.Shanghai Second University of Med.Science Affiliated Xinhua Hospital, Shanghai\ 200092;2.);HPLC Determination and Pharmacokinetic Study of Polydatin in Pig[J];Chinese Journal of Pharmaceutical Analysis;2001-05
9 LIANG Biao 1, CHEN Li-yan 1, JIN Xun-jie 2, PENG Bo 1 ( 1 Institute of Respiratory Disease, 2 Department of Bone Surgery, Guangdong Medical College, Zhanjiang 524021, China );The relationship between the activity of phospholipase A_2 and chronic hypoxic pulmonary hypertension[J];Chinese Journal of Pathophysiology;2002-05
10 CHEN Li-yan, LIANG Biao, PENG Bo, WU Jun (Institute of Respiratory Disease, Guangdong Medical College, Zhanjiang 524021,China);Effect of polidatin on the activity of phospholipase A_2 and pulmonary structural remodeling in rats with hypoxia-induced pulmonary hypertension[J];Chinese Journal of Pathophysiology;2002-08
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Zhu Zuojiang et al ( Department of Pathophysiology );The improvement of microcirculation in rat with irreversible hemorrhagic shock by crystal No 4 of polygonum cuspidatum[J];Journal of First Military Medical University;1987-02
2 Luo Sufang, Zhang Peiwen,Li Ruisong Department of Pharmacology, First Military Medical University;Dilating action of 3 , 4', 5 - trihydroxystibene - 3 -β -mono-D-glucoside on rabbit' s blood vessels[J];Journal of First Military Medical University;1992-01
3 Jin Xingzhong, Zhang peiwen Department of Pharmacology;Effect of polydatin on the myocardial functions in the isolated working rat heart*[J];Journal of First Military Medical University;1992-01
4 Wang Yaozhong,Huang Zikai,Zhang Peiwen Department of Pharmacology Department of Information, Nanfang Hospital;3,4’,5,trihydroxystibene-3-μ-mono-D-glucoside inhibited rabbitaorta strip contraction induced by histamine released from platelet[J];ACAD J ISI MED COLL PLA;1994-03
5 SHAO Yan-kun 1 ,WANG Xi-yuan 2 ,WANG Yue-hui 3 ,et al.(1.Department of Neurology,the First Hospital of Jilin University,Chang chun130021;2.Department of Orthopaedics,the First Hospital of Jilin University,Chang chun130021;3.Department of Pathology,Ba sic Med ical Science College,Jilin University,Chang chun130021,China);Primary culture of cortical neurons of newborn rat[J];Jilin Medical Journal;2003-02
6 Liu chunling,et al histology and embryology department of Mudanjiang Medical College.157011;THE STUDY OF MAKING AD MODEL BY INJECTING β_AP INTO HIPPOCAMPUS OF RATS[J];Journal of Mudanjiang Medical College;2001-03
7 YUAN Yong-gui,YE Qin,CHEN Yong,et al.Department of Psychiatry,Nanjing Brain Hospital Affiliated of Nanjing Medical University,Nanjing 210029,China;A Study of Serum Lipid Concentrations and Apolipoprotein E Genotype among Patients with Senile Depression and Alzheimer Disease[J];Chinese General Practice;2006-02
8 Wang Huaixing, Yao Zhibin, Gu Yaoming, Chen Yici (Brain Research Department, Sun Yat sen University of Medical Sciences, Guangzhou 510089);OVEREXPRESSION OF GLIAL FIBRILLARY ACIDIC PROTEIN IN SEPTUM MEDIALIS DIAGONAL BAND OF SENILE MEMORY DEFICITS RAT[J];CHINESE JOURNAL OF NEUROANATOMY;2000-01
9 JIN Wei-Jun,CHEN Shu-Yuan,QIAN Zhong-Xiu et al (Dept of Pharmacology, Nan fang Hospital, Guangzhou 510515);Effects of polydatin Ⅳ on inhibiting respiratory burst of PMNs and scavenging oxygen free radicals[J];Chinese Pharmacological Bulletin;1993-05
10 Albert WNLeung, ZX Mo (Department of Biology, Hongkong Baptist University, HongKong);Protective effects of polydatin, an active compound from polygonum cuspidatum, on cerebral ischemic damage in rats[J];Chinese Pharmacological Bulletin;1996-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved