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《Chongqing Medicine》 2011-24
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Protective effect of ischemic postconditioning on the intestinal ischemia-reperfusion in rats

Yuan Yong1,Guo Hao2,Zhang Yi1,Gan Ping1,Zhou Dong1,Chen Jiayong1(1.Department of Emergency,the Second Affiliated Hospital of Kunming Medical College,Kunming 650101,China;2.Department of Cardiology,Calmette Hospital,Kunming Medical College,Kunming 650011,China)  
Objective To investigate protective effect and mechanism of ischemic postconditioning on the rat model of intestinal ischemia-reperfusion.Methods Forty healthy SPF male rats were randomly divided into four groups.The sham group,which underwent a laparotomy and dissection of superior mesenteric artery(SMA) before the peritoneal cavity was closed;the IR group,undergoing mesenteric ischemia(45 minutes) and reperfusion(two hours);the IPr group,three cycles of ischemia alternated with three cycles of reperfusion lasting two minutes each were performed before 45 minutes ischemia and 120 minutes reperfusion;and the IPo group,undergoing ischemia(45 minutes) and reperfusion(two hours)(before the beginning of reperfusion,three cycles of reperfusion alternated with three cycles of ischemia lasting two minutes each were performed.At the end of procedure,the intestinal morphometric study was measured by Chiu′s classification,the TNF-α,IL-1β,IL-6 and IL-10 in serum were measured by ELISA and the colony forming units/g(CFU/g) were counted.Results The degree of pathological impaired of small intestine in IPr and IPo groups were lighter than IR group(P0.05).The IPr and IPo rats had enhancement of IL-10 and suppressed production of serum TNF-α,IL-1β and IL-6,compared to IR group rats(P0.05).The E.coli DH5α was hardly detected in the S group.And the levels of bacterial translocation in the IR group were higher than those of IPr and IPo groups(P0.05).Conclusion The IPo has a positive effect on lessening intestinal mucosa injury,on inhibiting secretion of proinflammatory cytokines,and reducing levels of the bacterial translocation.
【Fund】: 云南省自然科学基金资助项目(2009ZC106M)
【CateGory Index】: R574.5
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