Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chongqing Medicine》 2011-24
Add to Favorite Get Latest Update

Protective effect of ischemic postconditioning on the intestinal ischemia-reperfusion in rats

Yuan Yong1,Guo Hao2,Zhang Yi1,Gan Ping1,Zhou Dong1,Chen Jiayong1(1.Department of Emergency,the Second Affiliated Hospital of Kunming Medical College,Kunming 650101,China;2.Department of Cardiology,Calmette Hospital,Kunming Medical College,Kunming 650011,China)  
Objective To investigate protective effect and mechanism of ischemic postconditioning on the rat model of intestinal ischemia-reperfusion.Methods Forty healthy SPF male rats were randomly divided into four groups.The sham group,which underwent a laparotomy and dissection of superior mesenteric artery(SMA) before the peritoneal cavity was closed;the IR group,undergoing mesenteric ischemia(45 minutes) and reperfusion(two hours);the IPr group,three cycles of ischemia alternated with three cycles of reperfusion lasting two minutes each were performed before 45 minutes ischemia and 120 minutes reperfusion;and the IPo group,undergoing ischemia(45 minutes) and reperfusion(two hours)(before the beginning of reperfusion,three cycles of reperfusion alternated with three cycles of ischemia lasting two minutes each were performed.At the end of procedure,the intestinal morphometric study was measured by Chiu′s classification,the TNF-α,IL-1β,IL-6 and IL-10 in serum were measured by ELISA and the colony forming units/g(CFU/g) were counted.Results The degree of pathological impaired of small intestine in IPr and IPo groups were lighter than IR group(P0.05).The IPr and IPo rats had enhancement of IL-10 and suppressed production of serum TNF-α,IL-1β and IL-6,compared to IR group rats(P0.05).The E.coli DH5α was hardly detected in the S group.And the levels of bacterial translocation in the IR group were higher than those of IPr and IPo groups(P0.05).Conclusion The IPo has a positive effect on lessening intestinal mucosa injury,on inhibiting secretion of proinflammatory cytokines,and reducing levels of the bacterial translocation.
【Fund】: 云南省自然科学基金资助项目(2009ZC106M)
【CateGory Index】: R574.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 1 Hits
1 ZHANG Bin;LIU Hui-jie;ZHU Shao-hui;HE De-dong;FANG Xiang-jie;Department of General Surgery,the First Affiliated Hospital of Xinxiang Medical University;Department of Thoracic Surgery,the Third Affiliated Hospital of Xinxiang Medical University;;Protective effect of hydrogen saline combined with ischemic post-conditioning on intestinal ischemia reperfusion in rats[J];Journal of Xinxiang Medical University;2014-05
【Citations】
Chinese Journal Full-text Database 1 Hits
1 SHI Hong tao,DENG Zhi long,LENG En reng (Daping Hospital,the Third Military Medical University,Chongqing 400042);Study of protective effects of GuShenChangAn on intestines in rabbit during ischemia reperfusion[J];Chongqing Medical Journal;2002-02
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 YANG Hai-bo1,ZHANG Jing-zhe2,CAI Jun2,ZHANG Xue-lin2,SONG Hua-rong2 (1.Department of Colorectal Surgery,Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200062,China;2.Department of General Surgery,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China);Protective effect of Rhubarb and early enteral nutrition on intestinal mucosal barrier injury after ischemia-reperfusion in rats[J];Parenteral & Enteral Nutrition;2011-06
2 ZHENG De-yi1,2,WANG Jian-ming1,2,JIA Yi-tao1,FU Jin-feng 2,Lü Kai-yang1,LIAO Geng-jin1,2,ZHENG Xing-feng1,XIA Zhao-fan11.Department of Burns,Changhai Hospital,Second Military Medical University,Shanghai 200433,China2.Department of Burns,The Second Affiliated Hospital of Kunming Medical College,Kunming 650101,Yunnan,China;Role of p38 MAPK signaling in lung injury following intestinal ischemia/reperfusion in mice[J];Academic Journal of Second Military Medical University;2010-03
3 YIN Gang, WU Cheng-tang, WANG Yun-xing, LEI Shang-tong Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China;Expression of R-spondin1 in intestinal epithelium of mice with intestinal ischemia-reperfusion injury[J];Journal of Southern Medical University;2009-06
4 ;Progress in Neonatal Necrotizing Enterocolitis[J];International Journal of Pediatrics;2007-06
5 ;Clinical application and research of mesenteric multi-slice spiral CT angiography[J];International Journal of Medical Radiology;2011-02
6 WANG Wei+1, FANG Zhou-xi+2,WANG Qing+1, et al.(1. Department of Pathophysiology, Wenzhou Medical College, Zhejiang 325007, China; 2. Emergency department, the First Affiliated Hospital of Wenzhou Medical College, Zhejiang 325007, China);Effect of ligustrazini on the intestine ultrastructure characteristic following intestine ischemia reperfusion injury in rabbits[J];Journal of Hangzhou Medical College;2004-02
7 Impact of intra-abdominal hypertension on the intestineZHAO Yun-zhao,GONG Guan-wen,LI Ning,LI Jie-shou(PLA Research Institute of General Surgery,School of Medicine,Nanjing University / Jinling Hospital,Nanjing 210002,Jiangsu,China);Role of oxygen-free radicals in enterocyte apoptosis and bacterial translocation in abdominal compartment syndrome:[J];Journal of Medical Postgraduates;2009-10
8 LIU Ke-xuan,HUANG Wen-qi;Protective effects of preconditioning and postconditioning against the intestines I/R injury[J];China Continuing Medical Education;2010-04
9 LI Kun,LIU Chang-Jian,and QIAO Tong (Department of Vascular Surgery,the Affiliated Drum Tower Hospital of Medical School of Nanjing University,Nanjing,Jiangsu 210008,China);Revascularization in Superior Mesenteric Artery Occlusion:Retrospective Analysis of 38 Cases[J];Chinese Journal of Arteriosclerosis;2012-02
10 GAO Chang-jun,CHAI Wei,SUN Xu-de,et al.Department of Anesthesiology,Tangdu Hosipital,Fourth Military Medical University, Xi' an 710038, China;Protective effects of intraluminal hyperoxygenated solution infusion on intestinal mucosal barrier injury induced by ischemia-reperfusion[J];The Journal of Clinical Anesthesiology;2008-08
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 CAO Wei-hong,HU Sen,SUN Dan,et al. (Burn Institute,304th Hospital of PLA,Beijing 100037,China);Replication of an animal model of partial ischemia and reperfusion injury of intestine[J];Journal of Traumatic Surgery;2005-01
2 Guo Jianping, He Jingsong, Jiang Lihua, et al. Department of General Surgery, The People's Hospital of Yuebei, Shaoguan 512026;Influence of mild hypothermic ischemic preconditioning on liver ultrastructure damage followed ischemia-reperfusion injury[J];Guangdong Medical Journal;2001-06
3 Sun Kai, Liu Zhisu, Sun Quan Department of General Surgery, Zhongnan Hospital, Wuhan University, Wuhan 430071, China;Protective Effect of Ischemic Postconditioning on Hepatic Ischemia-Reperfusion Injury[J];Journal of Hubei Medical University;2004-02
4 WANG Peng,CHEN Jia-yong,YUAN Yong(Dept.of Emergency,The 2nd Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650101,China);The Relation between Intestinal Ischemia-reperfusion Injury and Intestinal Mucosal Cell Apoptosis[J];Journal of Kunming Medical University;2009-S2
5 ZHAO Juan,GU En-hua,ZHANG Kang-kang.Department of Anesthesiology,Tianjin Eye Hospital,Tianjin Medical University,Clinical College of Ophthalmology,Tianjin 300020,China;Protection effect of etomidate on the retina injury induced by intestinal ischemia-reperfusion in rats[J];The Journal of Clinical Anesthesiology;2011-03
6 SUN Shun-Chang1, WANG Guo-Feng1, ZHAO Yu-Fang1, ZHAO Ren-Liang2 1Department of Neurology, Qingdao Ninth People's Hospital, Qingdao 266002; 2Department of Neurology, Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, China;Effects of Focal Ischemia Preconditioning on VEGF Expression and Angiogenesis in Rats with Cerebral Ischemia[J];Chinese Journal of Clinical Neurosciences;2011-06
7 LEI Wei,ZHOU Jiang-qiao,WANG Ling-long,et al.(Department of Urology,Renmin Hospital,Wuhan University,Wuhan 430060,China);Comparative study of prevention of dan-shen root and cyclosporine A to transplant renal ischemia/reperfusion injury[J];Journal of Clinical Surgery;2005-06
8 TAN Dingyu,XIA Zhongfang,GENG Ping,et al.Subei People's Hospital of Jiangsu Province,Yangzhou 225001,China;Research on Intestinal Permeability and Bacterial Translocation in Rats With Intestinal Ischemia Reperfusion Injury[J];Journal of Internal Intensive Medicine;2007-04
9 LV Ke-zhi,YANG Wei-ping,ZHANG Min-jun,CHAI Wei-yao,LI Hong-wei. Department of Surgery,Shanghai Institute of Digestive surgery,Ruijin Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200025,China;The Protective and Therapeutic Effects of Radix Salviae Miltiorrhizae(RSM)in Warm Ischemia-Reperfusion Injury of the Murine Liver[J];Journal of Surgery Concepts & Practice;2007-03
10 Liu Guo-hua,Liang Yue-pei Department of Cardiothoracic Surgery,Affiliated Hospital of Guilin Medical University,Guilin 541001,Guangxi Zhuang Autonomous Region,China;Effect of ischemic preconditioning combined with ischemic postconditioning on ischemia reperfusion injury during lung transplantation[J];Chinese Journal of Tissue Engineering Research;2012-05
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved