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《Chongqing Medicine》 2012-04
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Effects of electroacupuncture combined with rTMS on gene expression of adrenocortical hormone receptor in centrum of anxiety rat model

Zhou Qizhi1,Wei Jiaolu1,Cai Dingjun1,Peng Xiaohua1,Yu Shuguang1,Zheng Zhong2,Fang Yangqi3 (1.Laboratory of Acu-moxibustion,College of Acu-moxibustion and Tuina,Chengdu University of TCM,Chengdu,Sichuan 610075,China;2.Mental Health Center,West China Hospital,Sichuan University,Chengdu,Sichuan610041,China;3.Acupuncture School of Affiliated hospital of Chengdu University of TCM,Chengdu,Sichuan 610041,China)  
Objective To explore the effects and partial mechanisms of centrum by electroacupuncture combined with repetitive transcranial magnetic stimulation(rTMS) in anxiety rat model.Methods The anxiety rat model was built by SPS,which was used to observe the anti-anxiety effects of electroacapuncture combined with rTMS.The gene expressions of MR and GR in the hippocampus and the prefrontal cortex were measured by RT-PCR.Results Emotional reaction in anxiety model could be reduced by three of therapeutics.Compared with electroacupuncture treatment and rTMS treatment,electroacupuncture combined with rTMS treatment showed more dominance.Compared with the model group,the gene expressions of GR in the hippocampus was significant increased in electroacupuncture combined with rTMS.Conclusion There is a cooperativity of anti-anxiety in the electric acupuncture combined with rTMS.Anti-anxiety effects of therapeutics are possibly related to modulation of the gene expressions of GR in the hippocampus.
【Fund】: 国家自然科学基金资助项目(30701125);; 四川省教育厅自然科学基金资助项目(07ZA018)
【CateGory Index】: R245;R749.72
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