Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chongqing Medicine》 2012-07
Add to Favorite Get Latest Update

Derivation and evaluation of prognostic equation to predict in-hospital mortality of 128 children with severe sepsis

Xiang Guoyan,Wang Yuzhong(Department of Pediatrics,Luohe Medical College,Luohe,He′nan 462002,China)  
Objective To derive a prognostic equation to predict mortality of children with severe sepsis,and provide scientific guidance for prognostic assessment and treatment scheme formulation.Methods 128 children with severe sepsis admitted to pediatric intensive care unit(PICU) were included perspectively,and their gender,age,vital signs,loboratory indicators and pediatric critical illness score(PICS) were collected.They were divided into death group(56 cases) and survival group(72 cases) according to their in-hospital survival condition.Cox proportional-hazards regression was employed to derive the prognostic equation to predict mortality and the receiver operator characteristic(ROC) curve was used to evaluate its diagnostic performance.Results Diffe-rences of indicators included such as age,serum albumin,platelet count,white blood cell count,pathogens,duration of mechanical ventilation,pediatric critical illness score(PCIS),septic shock and multiple organ dysfunction syndrome(MODS) demonstrated statistical significance when univariate analysis was conducted in death group and survival group.Covariates selected for multivariate Cox regression equation were age(HR=0.281,95%CI:0.122~0.643),PCIS(HR=0.222,95%CI:0.099~0.499) and MODS(HR=3.110,95%CI:1.408~6.869).Prognostic equation to predict mortality was:h(t|X)/h0(t)=Exp(-1.271 age-1.506PCIS+1.135MODS).The areas under the ROC curve of prediction in-hospital mortality of children with severe sepsis according to equation and three factors of equation in descending order were equation,PCIS,MODS and age.Conclusion Prognostic equation to predict mortality based upon comprehensive indexes including age,PCIS and MODS has a certain reference value for evaluation of prognosis of children with severe sepsis.
【CateGory Index】: R720.597
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 3 Hits
1 YANG Yan-wen1,2, WANG Ying2, LI Bi- ru2, ZHAO Li2, QIAN Juan2, REN Hong2 (1.Wenzhou Medical College, Wenzhou 325027, Zhejiang, China; 2. Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China);Risk factors associated with the death of childhood severe sepsis[J];Journal of Clinical Pediatrics;2009-01
2 LIU Juan,QIAN Su-yun (Emergency Center,Beijing Children's Hospital Affiliated to Capital Medical University,Beijing 100045,China);A single-center survey on pediatric sepsis and severe sepsis[J];Journal of Clinical Pediatrics;2010-01
3 REN Xiao-xu,SONG Guo-wei (Department of Emergency Medicine,the Capital Institute of Pediatrics,Beijing 100020,China);Pediatric Risk of Mortality Ⅲ Score and Pediatric Critical Illness Score[J];Journal of Applied Clinical Pediatrics;2006-06
Chinese Journal Full-text Database 10 Hits
1 Zhang Xin Department of Pediatrics, the First People's Hospital of Huainan, 232007;The changes and significance of serum electrolyte level in children with serious pneumonia[J];Anhui Medical Journal;2004-06
2 LIN Hong-hua(Department of Pediatrics,Anhui Provincial Children's Hospital,Hefei 230051,China);Effect of intravenous gamma globulin on infants with severe pneumonia[J];Journal of Bengbu Medical College;2007-05
3 LIU Ming-yue, ZHANG Qi, WANG Fei, et al (Department of Emergency, Children’s Hospital Affiated to Capital Institute of Pediatric, Beijing 100020);Efficacy of Omeprazole on digestive tract hemorrhage in critical diseased children[J];Beijing Medical Journal;2010-07
4 QIU Chun-lan1,WANG Xing-yong1,HE Yin2,et al.(1.Department of Pediatric Intensive Care Unit,Children′s Hospital,Chongqing Medical University,Chongqing 400014,China;2.Department of Pediatrics,Ninth People′s Hospital of Beibei District,Chongqing 400700,China);Evaluating prognosis factors for children admitted to pediatric intensive care unit[J];Chongqing Medicine;2009-15
5 WANG Li Jie, LIU Chun Feng, SU Yan QiDepartment of Pediatrics, Second Clinical College, China Medical University, Shenyang 110003 China;Dynamic Changes of Serum TNF-α,IL-1β and IL-6 in Children with Central Nervous System Diseases and the Systemic Inflammatory Response Syndrome[J];Chinese Journal of Contemporary Pediatrics;2002-04
6 Li-Jie WANG, Ya-Juan ZHAO, Chun-Feng LIU. Department of Pediatrics, Second Clinical College, China Medical University, Shenyang 110004, China;Relationship between gastrointestinal dysfunction and childhood critical illness[J];The Chinese Journal of Contemporary Pediatrics;2005-02
7 PENG Shu-Mei, SUN Ping, ZENG Jing, DENG Xue-Mei. Guangdong Province Maternal and Child Health Care Hospital, Guangzhou 510010, China;Cardiac function of children with bronchial asthma[J];Chinese Journal of Contemporary Pediatrics;2006-05
8 XIA Chan,HAN Guo-Qiang,YE Jing,SHAN Xiao-Ou,HE Shi-Jun.Department of Internal Medicine,Yuying Children′s Hospital,Wenzhou Medical College,Wenzhou,Zhejiang 325027,China;Contents of serum albumin after surgical operation in children with acute intussusception[J];Chinese Journal of Contemporary Pediatrics;2009-04
9 YIN Qiang,ZHOU Xiao-Yu,XIAO Ya-Ling,ZHONG De-Wu.Department of General Surgery,Second Xiangya Hospital,Central South University,Changsha 410011,China;Application of damage control surgery in serious pediatric abdominal surgery[J];Chinese Journal of Contemporary Pediatrics;2009-09
10 ZHENG Fangzhou,FENG Na.Maternity and Child Health Hospital of Linyi,Linyi 276001,China;Application of Bubble positive pressure breathing device in infant's disease[J];Clinical Medicine;2009-01
【Secondary Citations】
Chinese Journal Full-text Database 9 Hits
1 LIU Xue Mei, YU Jian, LUO Li Man Department of Pediatrics, General Hospital of Guangzhou Command, Wuhan 430070, China;Dynamic Variations of Serum Procalcitonin Levels in Neonates with Sepsis[J];Chinese Journal of Contemporary Pediatrics;2001-03
2 FANG Yi-bin,XIAO Zheng-hui,ZHU Yi-min,et al.Hunan Provincial Children Hospital,Changsha,410007,China;Correlation Analysis of Plasma TNF-α,D-lactate Levels and Serious Case Score[J];Journal of Chinese Physician;2003-07
3 Zhang Renyi, Xu Liang, Zhang Yuming, Tang Dinghua, Qiu Gang. Shanghai Children s Hospital, Shanghai 200040;Preliminary study on the relationship between the systemic inflammatory response syndrome and severe neonatal infection[J];The Journal of clinical Pediatrics;2002-11
4 CHEN Zhi-hong,ZHANG Ping (Department of Pediatrics,The Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,China);PATHOGENIC BACTERIA OF NEONATAL SEPTICEMIA: THE CHANGES IN TEN YEARS AND DRUG-RESISTANCE ANALYSES[J];Medical Journal of Qilu;2005-05
5 ZHANG Jian-hui, ZENG Qi - yi, TAO Jian - ping (Department of Pediatric Intensive Care Unit,Guangzhou Children's Hospital,Guangzhou 510120,China);Clinical Application of Pediatric Risk of Mortality Score in Pediatric Intensive Care Unit[J];Journal of Applied Clinical Pediatrics;2005-06
6 FU Hong-min,KUANG Feng-wu(Pediatric Intensive Care Unit,Children's Hospital Affiliated to Chongqing Medical University,Chongqing 400014,China);Advances in Diagnosis and Treatment of Pediatric Sepsis[J];Journal of Applied Clinical Pediatrics;2007-10
7 LU Guo-ping(Pediatric Intensive Care Unit,Children′s Hospital of Fudan University,Shanghai 200032,China);Some Issues of Severe Sepsis and Septic Shock in Children[J];Journal of Applied Clinical Pediatrics;2007-22
8 YANG Jin-hong,LI Xiang-yang, ZHANG Chu-nan (Yuying Pediatric Hospital, Wenzhou Medical College, Wenzhou 325027, China);Pathogens Causing Newborn′ Septicemia and Their Antibiotic Resistance[J];Chinese Journal of Nosoconmiology;2003-06
9 MIN Ding-hong, YU Shao-qing, WANG Xiao-ping, YI Dong-ying (Empyrosis Center, Senior Cadre Patient′s Room, Department of Infectious Disease, the First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330066, P.R.China);Study on rapid detection of bacterial in burn sepsis by 16SrRNA genes polymerase chain reaction[J];China Journal of Modern Medicine;2006-17
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved