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《Chongqing Medicine》 2014-30
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The effect of sevoflurane pretreatment or aftertreatment on intrapulmonary shunt for patients with one lung ventilation during thoracic surgical procedures

Zhang Hongqin;Wang Diping;Li Ping;Xiao Wei;Xu Lu;Department of Anesthesiology,the Third People′s Hospital of Chongqing;Department of Anesthesiology,the First People′s Hospital of Chongqing;  
Objective To study the effect of sevoflurane pretreatment or aftertreatment on intrapulmonary shunt for patients with one lung ventilation(OLV)during thoracic surgical procedures.Methods 80 ASA I or II patients underwent thoracic surgery with OLV were randomly divided into four groups(n=20for each):(1)Propofol group(group P);(2)Sevoflurane pretreatment group(group S1);(3)Sevoflurane aftertreatment group(group S2);(3)Sevoflurane whole-treatment group(group S3).Blood samples were taken from radial artery and right atrial blood before induction of anesthesia(baseline T.0),before OLV(sevoflurane pretreatment 30 min,T1),after OLV 30,60 min and before the end of OLV(T2-T4)and after the end of OLV(T5)for measurement of blood gases and calculation of Qs/Qt.The indexs of hemodynamics and relative clinical data were recorded.Results Arterial oxygen pressure of the four groups for OLV significantly reduced,when compared with double lung ventilation(P0.05),but there was no significant difference among the four groups(P0.05).Intrapulmonary shunt of the four groups for OLV significantly increased,when compared with double lung ventilation(P0.05),but intrapulmonary shunt of S1,S2 and S3groups significantly decreased,when compared with P group,and there was no significant difference for S1,S2 and S3groups(P0.05).ConclusionSevoflurane can decrease intrapulmonary shunt for patients during OLV,but there is no significant difference for pretreatment or aftertreatment or whole treatment and do not increase arterial oxygen pressure.
【Fund】: 重庆市卫生局基金资助项目(2012-2-217)
【CateGory Index】: R614
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