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《Chongqing Medicine》 2015-03
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The antifungal study of antibacterial peptide MUC7 combined with Bifidobacterium in vitro

Guo Bin;Xie Ning;Bai Shanshan;Li Jun′an;Tang Zhong;Department of Clinical Laboratory,Affiliated Hospital of North Sichuan Medical College;  
Objective To investigate the cooperative antifungal effect of antibacterial peptide MUC7 combined with Bifidobacteria in vitro.Methods The antifungal effect was observed and measured by viable count and the Oxford cup method.Results Two methods exhibited more potent antifungal effect on Candida albicans,Candida albicans,Candida krusei and Candida parapsilosis in MUC7 combined with Bifidobacteria group.The colonies′numbers in MUC7 combined with Bifidobacteria group were 2.00±1.13,2.00±1.42,5.00±2.03,2.00±1.39 respectively by viable counting,which was lower than thoes in the saline group and Bifidobacterium group(P0.01),these two groups were significant lower than those in MUC7group(P0.05);the inhibition zone in MUC7 combined with Bifidobacteria group were(29.00±2.17),(31.00±3.25),(29.00±2.89),(30.00±3.36)mm detected by the Oxford cup method,which showed a significantly difference with the saline group,Bifidobacterium group and MUC7group(P0.05).Conclusion Antibacterial peptide MUC7 combined with Bifidobacterium exhibits good antifungal effect which may provide a foundation for the further research on a new generation of antifungal Bifidobacterium preparation.
【Fund】: 四川省卫生厅资助项目(110303)
【CateGory Index】: R978.5
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