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《Infectious Disease Information》 2008-06
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Experimental research on Fufangbiejiaruangan inhibiting alcoholic hepatic fibrosis in rats

Li Fengyi,Sun Jinhui①,Tian Delu①,et al.302 Hospital of PLA,Beijing 100039,China ①Dongzhimen Hospital Affililated to Beijing University of Chinese Medicine,Beijing 100700,China  
Objective To explore the inhibiting effect of Fufangbiejiaruangan on alcoholic hepatic fibrosis in rats.Methods Forty Wister male rats were randomly divided into 4 groups,the control group,the model group,traditional Chinese medicine(TCM)treatment group and western medicine treatment group.The model group,TCM treatment group and western medicine treatment group were administered with intragastrical perfusion of"alcohol-pyrazole-corn oil"mixture and given high-fat diet for 16 weeks to prepare rat models of alcoholic hepatic fibrosis while the control group was given saline.Then TCM treatment group was treated with Fufangbiejiaruangan and western medicine treatment group with compound embryonic bovine liver extract tablets.After 4 weeks of treatment,hepatic fibrosis indices,liver tissue pathology and expression of transforming growth factor-β1(TGF-β1) in liver tissues were detected.Results Rat models of alcoholic hepatic fibrosisshowed abnormalhepaticfunction and obvioushepaticfibrosis.After4 weeksoftreatment,compared with the model group,alanine aminotransferase(ALT),aspartate aminotransferase(AST) and hyaluronic acid(HA) decreased significantly(P0.01) in the serum in the two treatment groups.It was shown by light microscopy that collagen content around hepatic sinusoids decreased obviously,and there was almost no fiber connection among blood sinusoids in rat livers of the two treatment groups.Immunohistochemistry showed that expression of TGF-β1 decreased significantly in TCM treatment group.Conclusion Fufangbiejiaruangan can inhibit the generation of collagen fibers and prevent the progression of hepatic fibrosis by down-regulating the expression of TGF-β1.Therefore,Fufangbiejiaruangan can inhibit and reverse the progression of alcoholic hepatic fibrosis in rats effectively.
【Fund】: 山东省自然科学基金青年基金(Q2005C04) 项目名称:酒精性肝纤维化细胞交互作用及活血化痰法的干预
【CateGory Index】: R575.29
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