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《Infectious Disease Information》 2009-01
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Changes in drug resistance of Mycoplasma from the patients with non-gonococcal urethritis

He Jing,Yang Jie,Li Hengjin,et al. General Hospital of PLA,Beijing 100853,China  
Objective To analyze Mycoplasma infection in non-gonoccocal urethritis (NGU) and the changes in drug resistance in order to provide the data of epidemiology and instruct rational application of antibiotics. Methods Mycoplasma culture and drug susceptibility test were carried out using one complex Mycoplasma kit in urethral discharge collected from NGU patients treated in our hospital from Nov. 2005 to Oct. 2008. Clinical data,including the age of patients,drug susceptibility,etc. were analyzed retrospectively. Results Of 1 353 NGU patients,the positive rate of Mycoplasma was 49.0%~54.6 %,of which that of Ureaplasma urealyticum (Uu),Mycoplasma hominis (Mh),Uu and Mh were 43.0%~47.0%,1.0%~1.4% and 5.0%~6.2%,respectively. There were no obvious changes in drug susceptibility of Uu to tetracyclines and great changes to macrolides. The drug susceptibility of Uu to quinolones decreased in 3 years. Mh was susceptible to tetracyclines and josamycin. Conclusions Mycoplasma,especially Uu was one of the main pathogens of NGU with great changes in drug resistance. Clinicians should focus on the changes in epidemiology and drug resistance in local areas so as to use antibiotics rationally.
【CateGory Index】: R759;R446.5;R695
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