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《Infectious Disease Information》 2012-06
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Epidemiological investigation on HIV/AIDS patients in Guangdong Province in 2011

ZHANG Jian-sheng, NIE Jing-min, HE Hao-lan, CAI Wei-ping* Department of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou, Guangdong 510060, China  
Objective To investigate the epidemiological characteristics of emerging HIV/AIDS patients in Guangdong Province in 2011. Methods Totally 835 HIV/AIDS patients with antibody positive and without receiving highly active antiretroviral therapy, who were treated in Guangzhou Eighth People's Hospital in 2011, were included in the study. Gender, age, routes of infection and other general data were recorded. CD4+ and CD8+ T lymphocyte counts, WBC, HGB, PLT, ALT, AST, TBIL, HBV markers and HCV antibody were detected. SPSS 13.0 software was used to describe and analyze the statistics. Results The mean age of the 835 HIV/AIDS patients was 39.7±11.8 years old. The infection rate in males (n=585, 70.1%) was higher than that in females (n=250, 29.9%). The infection routes were mainly sexual transmission (n=689, 82.5%), 557 patients (66.7%) through heterosexual transmission and 132 (15.8%) through homosexual transmission, intravenous drug abuse (n=126, 15.1%) and blood transfusion (n=20, 2.4%). Of the 725 HIV/AIDS patients with complete data, 514 (70.9%) were affected with HIV infection alone (group A), 103 (14.2%) with HIV/HBV coinfection (group B), 83 (11.4%) with HIV/HCV/HBV coinfection (group C), and 25 (3.4%) with HIV/HCV coinfection (group D). The four groups had significant differences in the infection routes (χ2=415.358, P=0.000), group A and B mainly through heterosexual transmission, and group C and D mainly through intravenous drug use. The level of PLT dropped in 65 patients (7.8%), and that of group B dropped more greatly than that of group A, and the difference between the two groups was significant (χ2=10.451, P=0.001). The coinfection might aggravate liver injury. AST level in coinfection groups (group B, C and D) increased more significantly when compared with single infection group (group A) (χ2AB=20.012, PAB=0.000; χ2AC=14.237, PAC=0.000; χ2AD=26.725, PAD=0.000). ALT level in group D was significantly higher than that in group A (χ2=8.395, P=0.004). TBIL level in group B was significantly higher than that in group A (χ2=9.130, P=0.003). Conclusions The emerging HIV/AIDS patients in Guangdong Province in 2011 are mainly young male adults, and the majority are infected through sexual transmission. The rate of HIV and HBV/HCV coinfection is higher, and the HIV patients coinfected with HCV are mainly infected through injection drug use. The coinfection is the important cause leading to the aggravation of liver injury and myelosuppression.
【Fund】: 国家“十二五”科技重大专项(2012ZX10001003-003)
【CateGory Index】: R512.91
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