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《Infectious Disease Information》 2018-04
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Effects of intestinal microbiota on cancer immunotherapy

JIN Yi;ZHENG Yi;ZHANG Hang-yu;ZHAO Peng;TU Xiao-xuan;WU Wei;LIU Lu-lu;FANG Wei-jia;Department of Traditional Chinese Medicine and Western Medicine, Peoples' s Hospital of Sanmen County;  
Recent studies indicate that intestinal microbiota plays an important role in cancer immunotherapy. Intestinal microbiota is closely related to the treatment effect of immune checkpoint inhibitors targeting cytotoxic T lymphocyte associated antigen 4, programmed cell death protein 1 and programmed cell death protein 1 ligand. Our study analyzes recent progress of related basic and clinical studies and finds that several bacteria such as Akkermansia muciniphila and Bifidobacterium can improve cancer immunotherapy efficacy and may act as a biomarker. Therefore, we conclude that diversified intestinal microbiota can maintain the stability of the internal environment, and equitable regulation of intestinal microbiota can improve the efficacy of cancer immunotherapy and reduce adverse reactions.
【Fund】: 浙江省重大科技专项(2017C03028)
【CateGory Index】: R730.51
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