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《Journal of Agricultural University of Hebei》 2008-02
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Study on experimental mastitis induced by Staphylococcus aureus in mice

LIU Ping1,2,HAO Man-liang1,QIN Jianhua1,YE Bao-na1,HOU Xi-cheng3,WANG Wei-yu1,XIE Fei1(1.College of Animal Science and Technology,Agricultural University of Hebei,Baoding 071001,China;2.The First Middle School of Cangzhou,Cangzhou 061001,China;3.College of Forestry,Agricultural University of Hebei,Baoding 071001,China)  
To establish mice mastitis model,thirty-five lactating BALB/C female mice were random1y divided into seven groups.50 μL of sterile physiological saline solution(PSS) or different concentration of Staphylococcus aureus were injected into the fourth abdominal mammary gland via the teat duct at 8~10 d after parturition.The changes of temperature,histopathologic evaluations,interstitial width,alveoli cases thickness from each group and colony for units(CFU),Tumor necrosis factor-α(TNF-α)and interleukin-γ(IFN-γ) concentration in the mammary glands were examined.The results showed that the temperature of treatment groups decreased at the beginning,and then increased,particularly in T3 group.Histopathologic examination of mammary gland revealed that the number of polymorphonuclear neutrophils(PMN) and exfoliated epithelial cells were present in alveoli cases,with increased interval width,and inflammation of the mammary glands was significant.Along with the increase of dose,pathological changes of mammary glands became more serious.The interstitial width of T3 group was wider than those of other groups.In comparison with those of PSS-treated mice,alveoli cases thickness,CFU,TNF-α and IFN-γ concentration were significantly(P0.01)higher in 50 μL1.4×104 CFU/mL Staphylococcus aureus-infused mammary glands.The results demonstrated that the mice experimental mastitis model infused with Staphylococcus aureus via teat duct was the same as immunopathology and inflammatory response,and can be used as a pathological model.
【Fund】: 国家十一五重大专项子专题“华北农区奶牛疾病综合防治技术应用与示范”(2006BAD04A10-4)
【CateGory Index】: S858.23
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