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The effect of short-chain fatty acids(SCFA) on graft morphology and absorption after rat small bowel transplantation

LI Kezhou, LI Ling, LI Jieshou, BAO Yang, LI Yousheng (Research Institute of General Surgery Jinling Hospital,Nanjing 210002,Jiangsu,China)  
Objectives:To study the effect of shortchain fatty acids(SCFA) on morphology and absorption of small bowel graft. Methods:Heterotopically total small bowel transplantation was made with inbred Wistar(PT1k) rats,and either total parenteral nutrtion(TPN group,n=10) or shortchain fatty acids supplemented TPN(SCFA group,n=10) was used in recipients from POD2 to POD10. Results:Mucosal villous hight,crypt depth,mucosal thickness and villous sur face area were found significantly increased in SCFA group compared with TPN group.Atrophied microvilli and broken mitochondrial crista were observed in TPN group,higher microvilli and less damaged mitochondrial crista were seen in SCFA group.Recipient plasma 15 NGlycine amount was found greater at all the 1st,2nd,3rd hour time points in SCFA group than in TPN group. Conclusions:Shortchain fatty acids can improve mucosal morphology,preserve enterocyte ultra structure,and enhance amino acid absorption of isograft after small bowel transplantation in rat.
【CateGory Index】: R965
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