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《Parenteral & Enteral Nutrition》 2002-01
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The effects and the mechanisms of exogenous fatty acids on colorectal cancer cells

CAI Wen wei 1, HUA Tian fang 2,CAO Jun 2, GU Qing 2, SHI Dun 1 (1.Department of General Surgery, Zhejiang Provincial Hospital,Hangzhou 310014,Zhejiang,China; 2.Department of General Surgery,Shanghai First People's Hospital,Shanghai,200080,China)  
Objectives: To observe the effects and the mechanisms of exogenous fatty acids on colorectal cancer cells(LoVo). Methods:The effect of exogenous fatty acids on LoVo cells was determined by 5 diphenyl tetrazolium bromide(MTT) assay.The content of MDA was examined to evaluate the extent of lipid peroxidation. Results:The growth of LoVo cells was inhibited by polyunsaturated fatty acids(PUFAs).The inhibitory effect of saturated fatty acids and monounsaturated fatty acids on LoVo cells was not showed.None of the fatty acids was found to fibroblast cells(HLF).PUFAs caused the significant rising of intracellular MDA content. Conclusions:PUFAs could inhibit the growth of colorectal cancer cells.The strengthening of lipid peroxidation may be one of the mechanisms.
【CateGory Index】: R735.35
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