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《Parenteral & Enteral Nutrition》 2004-03
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The effects of enteral nutrition on liver injury and albumin gene transcription in obstructive jaundice rats

XU Ren ying 1,CAO Wei xin 2,CHEN Xue hua 3,ZHANG Ming jun 3,ZHANG Yi 3 (1.Department of Clinical Nutrition,Shanghai Renji Hospital,Shanghai 200001,China;2.Department of Clinical Nutrition,Shanghai Ruijin Hospital,Shanghai 200025,China;3.Research Institute of Gastrointestinal Surgery,Shanghai Ruijin Hospital,Shanghai 200025,China)  
Objectives: To evaluate the effects of enteral nutrition on liver injury and albumin gene transcription in obstructive jaundice rats. Methods: Forty male SD rats were randomly divided into SHAM group and CBDL group, the later was further divided into three groups: control group, CBDL+Nutrison group and CBDL+Nutrison fiber group( n =10). Isocaloric and isonitrogenous nutritional formulae were given to all the rats for five days. Total calorie was 630 kJ/(kg·d) and nitrogen amount was 1.2 g/(kg·d). Results: Liver function was obviously injured by CBDL. Liver function in the Nutrison and Nutrison fiber groups were similar compared with that in the control group. Nutrison and nutrison fiber maintain body weight better than normal diet, but showed no obvious effects on serum protein and albumin. The expression of liver ALB mRNA and DBP mRNA was obviously higer in the SHAM group than that in the CBDL group. The expression of liver ALB mRNA showed an increasing tendency in the Nutrison and Nutrison fiber groups than that in the control group, but without statistical difference. Nutrison was similar to nutrison fiber in weight loss, serum protein, liver function and albumin gene transcription. Conclusions: Enteral nutrition for short time did not aggravate liver injury in the obstructive jaundice rats. Nutrison and Nutrison fiber maintained body weight better than normal diet, but showed no obvious effects in serum protein and albumin gene transcription.
【CateGory Index】: R657.4
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