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《Parenteral & Enteral Nutrition》 2011-06
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Protective effect of Rhubarb and early enteral nutrition on intestinal mucosal barrier injury after ischemia-reperfusion in rats

YANG Hai-bo1,ZHANG Jing-zhe2,CAI Jun2,ZHANG Xue-lin2,SONG Hua-rong2 (1.Department of Colorectal Surgery,Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200062,China;2.Department of General Surgery,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)  
Obiective: To observe the effect of Rhubarb and early enteral nutrition on intestinal mucosal barrier injury after intestinal ischemia-reperfusion.Methods: Thirty-two Sprague-dowley rats were randomly divided into control,rhubarb,EN and Rhubarb-EN group.A rat model of intestinal ischemia-reperfusion was constructed by clamping the supramesenteric artery.The rats were killed at the 24th hour after reperfusion.Morphologic changes of intestinal mucosa,endotoxin and bacterial translocation in mesenteric tissue,spleen,and liver were determined. Results: After intestinal ischemia-reperfusion,intestinal mucosa was damaged seriously.At the 24th hour after intestinal ischemia-reperfusion,the level of plasma endotoxin in Rhubarb group was lower than that in EN group(P0.05).Bacterial translocation was found in all groups.Bacterial translocation decreased significantly in both Rhubarb group and Rhubarb-EN group compared with both control group and EN group.2×2 factorial ANOVA of V/C ratio showed significant synergistic effect in the interaction of factor Rhubarb and EN.Conclusion: Eeffect of early enteral nutrition added Rhubarb on intestinal mucosal barrier injury after ischemia-reperfusion was benefitial in rats.
【CateGory Index】: R459.3
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