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《Parenteral & Enteral Nutrition》 2012-02
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Pathological effects of 3 kinds of fat emulsions on acute lung injury in rats

HUANG Li-mi1,SHI Ji-peng2,YU Zhen3,XU Dan4(1.Department of Pedirtrics;3.Department of Gastrointestinal Surgery,First Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000,Zhejiang,China;2.Department of Pedirtrics,First Affiliated Hospital of Xinxiang Medical College,Weihui 453100,Henan,China;4.Department of Pedirtrics,Second Affiliated Hospital of Nanchang University,Nanchang 330006,Jiangxi,China)  
Objective: To investigate the effect of the fat emulsion pretreatment on acute lung injury(ALI) in rat.Methods: 100 Sprague-Dawley rats were randomly divided into five groups,namely blank group,LPS group,Intra Group,Clino Group,and the Omega Group.And then three kinds of fat emulsion or normal saline were used to pretreat the rats for 7 days.On the 7th day,LPS was used to introduce ALI.8 hours later,lung tissues were examined.Results: Compared with the blank group,the lung indexes,pathological scores and apoptosis index were significantly higher in ALI rats(P0.05 or P 0.01).The pathological scores in parenteral nutrition groups were significantly lighter than in LPS group(P0.05 or P0.01).The apoptosis index in Clino group and Omega group was significantly lighter than in LPS group(P0.05 or P0.01).Conclusion: Clinoleic and Omegaven can reduce pathological changes of ALI in rats.
【Fund】: 浙江省医学重点扶植学科“临床营养学”(2007-F03)
【CateGory Index】: R563.8
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