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《Journal of Chuxiong Normal University》 2008-12
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Establishment of Experimental Animal Model of Intestinal Microflora Dysbiosis

YANG Xiao-yan;LI Hui;SU Hong-yan(School of Life Science and Chemistry,Dali University,Dali 671000,China)  
To establish a mice model of gastrointestinal microflora imbalance,the mice were orally inoculated with Erythromycin Lactobionatefor Injection(2.94g/kg),Cefalexin(6.19g/kg),Lincomycin Hydrochloride Injection(2.02g/kg) and Ampicillin Capsules(5.5g/kg) there times each day for 10 days.The colony of bacillus and coccus in rectum and cecum were detected everyday between 2 and 16 days postinoculation(p.i.).The Results show that during the term of inoculation,the colony of coccus in rectum and cecum gradually increased and become the prominent bacteria in the intestine.By the 16 days p.i.,the levels of bacillus and coccus recovered gradually and near to the control mice except the lactic acid group.Finally,the Conclusions were drawn below: the results suggest that four antibiotics can stably induce intestinal microflora dysbiosis in mice.Inhibiting effect of Lincomycin Hydrochloride on bacillus is very stable and lasting than others.
【CateGory Index】: R-332
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