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《Journal of Traumatic Surgery》 2001-02
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Investigative progress in prophylaxis and treatment of ARDS with ambroxol

ZHAO Yun-ping, JIANG Yao-guang (Thoracic Surgery Center of Daping Hospital, Third Military Medical University Chongqing 400042, China)  
Ambroxol is probably one of the most promising surfactant stimulating agents. It was paid much attention to its protective action in respiratory system in recent years, Ambroxol was applied in prophylaxis and treatment of ARDS and gained better clinical effect. The mechanism of prophylaxis and treatment of ARDS maybe: (1 ) decreasing release of pro-inflammatory(TNFα, IL-1 ) and correlative cytokines, relieving the manifestation of SIRS in lung; (2 ) enhancing of anti-oxidant defence mechanisms, preventing lung injury by reactive free oxygen radicals (e. g.. OH, HOCl); (3 ) stimulating synthesis and excretion of endogenetic pulmonary surfactant (PS) by lung alveolar type Ⅱ cells, preventing degradation of PS by phospholipase A, increasing compliance of lung; (4) relieving destruction potential difference of trachea wall in ARDS. There mayb have better clinical effect in prophylaxis and treatment of ARDS with Ambroxol.
【CateGory Index】: R563.8
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