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《Journal of Traumatic Surgery》 2001-03
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Establishment of a lung contusion combined with endotoximia induced lung injury model and its early characteristics of lung inflammation response

LU Jia kai,YANG Zhi huan,JIANG Jian xin, et al. (Surgery Institute of Daping Hospital, Third Military Medical University,Chongqing,400042 China)  
Objective To establish a model of lung contusion combined with endotoxemia induced lung injury, and observate its characteristics of inflammatory response and evaluate the relationship between the inflammation response and the injury severity in this model.Methods Lung contusion and endotoxmic lung injury model were intruduced by bio impact apparatus and lipopolysaccharide injection through vail vein respectively. Lung contusion combined with endotoxemia induced lung injury model was introduced by lung contusion following lipopolysaccharide injection using same index of impact and same dose of lipopolysaccharide. Parameters such as mortality, RLW, PaO 2 were evaluated and inflammatory mediators in branchalveolar lavage fluid (BALF) were assayed. Results The mortality of this model during 48 hours was 57.5% , that was significantly higher than that of other two models. The elevation of RLW and the decrease of PaO 2 were more significant in lung contusion combined with endotoxemia acute lung injury model than in other two models. Following injury, an obvious inflammatory response was observed by BALF mediators assay in this model.Conclusion Lung contusion combined with endotoxemia induced lung injury model is a acute lung injury model with a severity that is more significant than lung contusion model or endoxemia lung injury model. Evident inflammatory response that is presented by inflammatory mediators in BALF processes in lung tissue following trauma. The level of lung inflammatory response following trauma is the important element that influence the severity of lung injury and outcome.
【CateGory Index】: R655.3
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