Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Traumatic Surgery》 2001-03
Add to Favorite Get Latest Update

Establishment of a lung contusion combined with endotoximia induced lung injury model and its early characteristics of lung inflammation response

LU Jia kai,YANG Zhi huan,JIANG Jian xin, et al. (Surgery Institute of Daping Hospital, Third Military Medical University,Chongqing,400042 China)  
Objective To establish a model of lung contusion combined with endotoxemia induced lung injury, and observate its characteristics of inflammatory response and evaluate the relationship between the inflammation response and the injury severity in this model.Methods Lung contusion and endotoxmic lung injury model were intruduced by bio impact apparatus and lipopolysaccharide injection through vail vein respectively. Lung contusion combined with endotoxemia induced lung injury model was introduced by lung contusion following lipopolysaccharide injection using same index of impact and same dose of lipopolysaccharide. Parameters such as mortality, RLW, PaO 2 were evaluated and inflammatory mediators in branchalveolar lavage fluid (BALF) were assayed. Results The mortality of this model during 48 hours was 57.5% , that was significantly higher than that of other two models. The elevation of RLW and the decrease of PaO 2 were more significant in lung contusion combined with endotoxemia acute lung injury model than in other two models. Following injury, an obvious inflammatory response was observed by BALF mediators assay in this model.Conclusion Lung contusion combined with endotoxemia induced lung injury model is a acute lung injury model with a severity that is more significant than lung contusion model or endoxemia lung injury model. Evident inflammatory response that is presented by inflammatory mediators in BALF processes in lung tissue following trauma. The level of lung inflammatory response following trauma is the important element that influence the severity of lung injury and outcome.
【CateGory Index】: R655.3
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Co-citations】
Chinese Journal Full-text Database 3 Hits
1 Qin Zonghe,Liu Zhangwen,Zhou Minggen,et al.Department of ICU.Affiliated Hospital of Bengbu Medical College,Anhui 233004;Clinical study of positive end-expiratory pressure ventilation in the treatment of acute lung injury[J];JOURNAL OF EMERGENOY MEDICINE;2000-01
2 Guo Faling, Yah Hongxia, Gao Guojun, et al.Tunghwa Hospital, Dong Guan, Guang Dong, 523000;Clinical Analysis of 16 Case of Acute Respiratory Distress Syndrome Treated by Ventilator[J];Lingnan Journal of Emergency Medicine;2000-03
3 ZHUANG Rong,YING Bin yu,CHEN Hao. Department of ICU,the Second Affilicated Hospital of Wenzhou Medical College,Wenzhou 325027;Treatment of acute respiratory distress syndrome by PEER using the pressure-volume curve[J];Journal of Wenzhou Medical College;2001-04
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Sun Chcngwen,Lǚ Wenwei, Lei Chunli,Wu Yan,Chen Yu)(Dept.of physiogy; Dept.of physiologcal Central lad.,Basic College of Med. Sci.;Elect roph ysiological Lab.of the First Teaching Hospital);Effects of Astragal us saponins on experimental heart fail ure([J];JOURNAL OF NORMAN BETHUNE UNIVERSITY OF MEDICAL SCIENCE;1994-02
2 ZHANG Fan (Capital College of Physical Education, Beijing 100088);Research Progress of 1,6-disphosphate Applying on Sports[J];Journal of Beijing Teachers College of Physical Education;2003-03
3 Zhang Zhiyong,Guo Menghe, Li Guangwen,et al. (Department of Thoracic Surgery,88th Hospital of PLA,Taian 271000) 〔;Analysis of the Characteristics and Treatment of 116 Cases with Thoracic Injuries in Traffic Accident[J];JOURNAL OF TRAUMATIC SURGERY;2000-01
4 Jia Jian,Jin Hongbin,Wang Ji (Tianjin Emergency and Traumatology Center,Tianjin Hospital,Tianjin 300211) 〔;Features of Multiple Trauma and the Countermeasures aginst It[J];JOURNAL OF TRAUMATIC SURGERY;2000-01
5 MA Xiao lin, YANG Zhi huan, WANG Zheng guo,et al. (Department of General Surgery, Daping Hospital, Third Military Medical University, Chongqing,China 400042);Establishment of stretch injury model of in vitro cultured primary liver cells and observation on changes of their cytoskeleton and viscoelasticity[J];Journal of Traumatic Surgery;2001-01
6 LIAO Ke long,ZHU Pei fang, WANG Zheng guo,et al. (Department of Cardiothoracic Surgery,Southwestern Hospital,Third Military Medical University, Chongqing, 400038, China);An animal model of lung injury following impact thoracic trauma in rats[J];Journal of Traumatic Surgery;2001-04
7 HUANG Xian kai,JIANG Yao guang,ZHOU Jian,et al. (Department of Traumatic Surgery,Daping Hospital,Third Military Medical University,Chongqing 400042,China);Characteristics and management of injury in patiens with severe multiple trauma[J];Journal of Traumatic Surgery;2002-06
8 QI Wei,JIAN Hua gang,ZHOU Ji hong,et al. (Department of Information,Daping Hospital,Third Military Medical University,Chongqing 400042);Study on the characteristics of drivers involved in traffic accident in Chongqing[J];Journal of Traumatic Surgery;2002-06
9 ;Epidemiological characteristics of 4000 traffic injuries[J];Journal of Traumatic Surgery;2003-02
10 GAO Jin-mou (Department of Traumatology,Chongqing Emergency Medical Center,Chongqing 400014,China);Clinical characteristic and severity evaluation of traffic injury[J];Journal of Traumatic Surgery;2005-04
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved