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《Journal of Traumatic Surgery》 2001-04
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An animal model of lung injury following impact thoracic trauma in rats

LIAO Ke long,ZHU Pei fang, WANG Zheng guo,et al. (Department of Cardiothoracic Surgery,Southwestern Hospital,Third Military Medical University, Chongqing, 400038, China)  
Objective To establish a novel animal model of impact lung injury in rats.?Methods The lung injury was made by multi function mini type bio impact machine developed by our department. The drive pressures were 250kPa, 350kPa,400kPa and 500kPa on the right lateral superior chest of the rats.?Results The severity of lung injury was positively related with the drive pressure. Severe and secondary lung injury could be obtained with drive pressure 400kPa.?Conclusion The animal model of severe lung injury can be obtained by multi function mini type bio impact machine. This model proves to be relatively simple, reliable and stable, which could provide for experimental study of severe impact lung injury.
【Fund】: 国家重点基础研究发展规划项目 (G1 9990 542 0 3);; 全国优秀年青教师基金
【CateGory Index】: R-332;R655
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【Co-citations】
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1 MENG Yi,YANG Kan,WANG Xiang yang,et al. (Department of Thoracic and Cardiovascular Surgery,473th Hospital of PLA,Lanzhou 730070,China);Clinical analysis of acute respiratory distress syndrome caused by pulmonary contusion[J];Journal of Traumatic Surgery;2004-04
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