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《Journal of Traumatic Surgery》 2001-04
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An animal model of lung injury following impact thoracic trauma in rats

LIAO Ke long,ZHU Pei fang, WANG Zheng guo,et al. (Department of Cardiothoracic Surgery,Southwestern Hospital,Third Military Medical University, Chongqing, 400038, China)  
Objective To establish a novel animal model of impact lung injury in rats.?Methods The lung injury was made by multi function mini type bio impact machine developed by our department. The drive pressures were 250kPa, 350kPa,400kPa and 500kPa on the right lateral superior chest of the rats.?Results The severity of lung injury was positively related with the drive pressure. Severe and secondary lung injury could be obtained with drive pressure 400kPa.?Conclusion The animal model of severe lung injury can be obtained by multi function mini type bio impact machine. This model proves to be relatively simple, reliable and stable, which could provide for experimental study of severe impact lung injury.
【Fund】: 国家重点基础研究发展规划项目 (G1 9990 542 0 3);; 全国优秀年青教师基金
【CateGory Index】: R-332;R655
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1 Huang Yi1,Wu Qiuping2,Yu Zubin2,Min Jiaxin2(1.Department of Thoracic Surgery,the 324th Military Hospital of PLA,Chongqing 400020,China; 2.Department of Thoracic Surgery,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China);The animal modelling of the collision injury of chest leading to the heart-lung injury[J];Chongqing Medicine;2012-30
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1 MENG Yi,YANG Kan,WANG Xiang yang,et al. (Department of Thoracic and Cardiovascular Surgery,473th Hospital of PLA,Lanzhou 730070,China);Clinical analysis of acute respiratory distress syndrome caused by pulmonary contusion[J];Journal of Traumatic Surgery;2004-04
2 ZHANG Zheng-fu,DU Ding-yuan,XIANG Xiao-yong(Department of Cardiothoracic Surgery,First Affiliated Hospital,Chongqing Medical University,Chongqing400036,China);Advances in diagnosis and treatment of pulmonary contusion[J];Journal of Traumatic Surgery;2009-02
3 ;Mechanical ventilation for treatment of pulmonary contusion:retrospective analysis of 50 cases[J];Journal of Traumatic Surgery;2009-05
4 LIAO Ke-long, ZHU Pei-fang, WANG Zheng-guo, LI Lei, YIN Zhi-yong, JIANG Jian-xin (Department of Cardiothoracic Surgery, Southwest Hospital, Third Military Medical University, Chongqing 400038, China);Effect of pyrrolidine dithiocarbamate on TNFα, IL-8 content and their mRNA expres- sion in traumatic acute lung injury in rats[J];Acta Academiae Medicine Militaris Tertiae;2001-08
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2 LIU Xiang-Yan, CHEN Gang, WANG Zhou, LIU Fan-Ying Department of Thoracic Surgery, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, 250021, P. R. China;Clinical Significance of Detecting Mucin 1 mRNA in Diagnosing Occult Lymph Node Micrometastasis in Esophageal Cancer Patients[J];Chinese Journal of Cancer;2007-02
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4 ZHANG Fan (Capital College of Physical Education, Beijing 100088);Research Progress of 1,6-disphosphate Applying on Sports[J];Journal of Beijing Teachers College of Physical Education;2003-03
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9 ZHANG Ming, HE Li-sheng, BO Bin, et al . (Department of Oral & Maxillofacial Surgery, Stomatological College, Fourth Military Medical University, Xi' an 710032, China);A study on maxillofacial impact injury associated with brain injury[J];Journal of Traumatic Surgery;2001-02
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