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《Journal of Traumatic Surgery》 2003-06
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Experimental study on the changes of GluR2 on post-synaptic membrane and its related brain secondary injury

LIU Bao song,LONG Zai yun,ZENG Lin,et al. (Research Institute of Surgery,Daping Hospital,Third Military Medical University,Chongqing 400042,China)  
Objective To explore the changes of GluR2 on the post synaptic membrane,ion permeable function of AMPA receptor and the effects on the delayed death of neuron.Methods The neuron death and the quantity of GluR2 on post synaptic membrane was quantitated with PI staining and double immuno fluorescence labeling. The mEPSCs (miniature excitatory postsynaptic currents) was measured with patch clamp.Results The number of delayed death neuron increased significantly after OGD (oxygen glucose deprivation). The total surface GluR2,the number of synapse with GluR2,and the quantity of GluR2 in synapse were marked lower than that of control group. OGD induced reduction of GluR2 mainly occurred at synapses. OGD also resulted in the increased expression of functional GluR2 lacking AMPA receptors at postsynaptic membrane.Conclusion OGD induced the reduction of GluR2 at postsynaptic membrane and the formation of GluR2 lacking AMPA receptors,which mediated the influx of Ca 2+ and resulted the delayed neuron death.
【CateGory Index】: R651.15
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