Clinical significance of shift of plasma IFN-γ、IL-4 cytokines in patients after trauma
LI Bin,WEN Liang,LIU Ming hua,et al. (Department of Emergency,Southwest Hospital,Third Military Medical University,Chongqing 400038,China)
Objective To evaluate the clinical significance of the shift plasma of IFN γ/IL 4 cytokines in patients after trauma.?Methods Thiry five patients with mechanical injury were investigated.?Blood collection was started 24h after injury,and blood samples were obtained at 3、5、7d post trauma in 35 cases respectively.?The plasma levels of IL 4 and IFN γ were measured by enzyme linked immuno sorbent assay(ELISA).?The relationship was analyzed between the levels of IFN γ、IL 4、IFN γ/ IL 4 and APACHEⅡ score,complications and prognosis in patients.?Results The drop of the level of blood IFN γ began at 5d post trauma and peaked at 7d post trauma.?The level of plasma IL 4 fluctuated and increased after trauma.?The ratio of IFN γ/ IL 4 decreased successively,and the ratio in patients with MODS was significantly lower than that without MODS(P0.05).?Furthermore,the ratio was correlated negatively with APACHEⅡ score(r=-0.622,P0.05),and significantly correlated negatively with the rate of infection(r=-0.868,P0.01).?Conclusion The drop of IFN γ/IL 4 appeared after trauma,which was closely correlated with immunological function and prognosis.
【CateGory Index】： R641