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《Science of Sericulture》 2007-01
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Reaction Condition of Fibroin Membrane Surface Grafting With Heparin and Anticoagulating Effect in vitro

YE Yong1 ZHANG Jian-Yun1 HUANG Long-Quan2* (1College of Life Sciences,Anhui Agricultural University,Hefei 230036,China;2College of Tea & Food Science,Anhui Agricultural University,Hefei 230036,China)  
Fibroin membrane surface was actived by the plasma processing,and then grafted with heparin via glutaraldehyde,from which the fibroin membrane has anticoagulating ability.The test provides the basis for the clinical practice and the design of new anticoagulating material for medical use.The result from single factor optimization showed that the better reaction condition for heparin and fibroin membrane,processed by the plasma and glutaraldehyde,was pH 1.5,temperature 40 ℃,time 4 hours.Under this condition the heparin content was 37.62 μg/g in fibroin membrane surface.Coagulant test in vitro showed that the fibroin membrane grafted with heparin has good anticoagulating;The compound was stable and not easily to be eluted in the stability test,suggesting that heparin was grafted with the fibroin membrane by covalent bond.
【Fund】: 安徽省教育厅自然科学重点科研项目部分内容(编号2005kJ393ZD)
【CateGory Index】: R318.08
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