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《Science of Sericulture》 2008-03
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Bioinformatics Analysis of 3-hydroxy-3-methylglutaryl-CoA Reductase(HMGR) in Isoprenoid Biosynthesis of Mulberry

LEI Wei1 TANG Shao-Hu1 ZHOU Qi-Gui1 SHUI Xiao-Rong1,2 SUN Yi-Ming1 SUN Min1* (1Key Laboratory of Eco-environments in Three Gorges Reservoir Region,Ministry of Education,College of Life Science,Southwest University,Chongqing 400715,China;2South China Botanical Garden,Chinese Academy of Sciences,Guangzhou 510650,China)  
The nucleic acid sequences and amino acid sequences of the key isoprenoid synthase 3-hydroxy-3-methylglutaryl-CoA reductase(hmgr) gene from mulberry,which were registered in GenBank,were analyzed by some bioinformatics tools including Vector NTI Suit 8 and so on.The results showed that the nucleic acid sequences in GenBank is genomic DNA of hmgr,and its gene arranges from 1 to 5 905 bp,including promoter,coding sequence and intron.It can speculate that the HMGR protein lies in Mitochondria,with transmembrane topological structure and plastid transport peptide of 22 amino acid residues,and is a hydrophic protein with HMG-CoA-reductase-classⅠdomain.The secondary structure of HMGR mainly consists of α-helix and random coil and the tertiary structures contains two HMG-CoA binding motifs and two NADP(H) binding motifs.
【Fund】: 三峡库区生态环境教育部重点实验室开放基金项目(编号EF200609)
【CateGory Index】: S888.2
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