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《Science of Sericulture》 2009-04
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The Regulation of Mouse Immune Functions by olysaccharides From Mulberry Bark

FEI Jian-Ming1 ZHAO Li-Hua1 ZHAN Peng-Fei1 SHI Guo-Fang1 ZHU Xiang-Rui2(1Huzhou Agricultural Academy of Zhejiang Province,Huzhou Zhejiang 313000,China;2College of Animal Sciences,Zhejiang University,Hangzhou 310029,China)  
Polysaccharides have regulatory effects on animal′s immunity and can be extracted from mulberry bark.Normal mice and immuno-depressed mice were lavaged with 300,600 and 900 mg/kg of mulberry bark polysaccharide extraction,respectively.The control group was given with equal amount of distilled water.The lavage was conducted once a day for 7 consecutive days.The changes of several physiological and biochemical indexes inside mouse body were measured and observed to understand the regulatory effect of mulberry bark polysaccharides on mouse immune functions.The results showed that mulberry bark polysaccharides could enhance DTH caused by 2,4-dinitrofluorobenzene in normal mice,promote development of immune organs and increase proliferation of spleen lymphocytes.The amount of mouse serum hemolysin antibodies,the ability of carbon clearance,NK cell activity,and the concentration of interleukin 2 of the tested group were all significantly higher than the control group(P0.05).Moreover,mulberry bark polysaccharides had certain effects on enhancing immune functions of the immuno-depressed mice.Except the phagocytic ability of the macrophages,all other indexes measured were significantly improved.It is concluded that mulberry bark polysaccharides can improve physiological and biochemical indexes of mouse immune functions and has a certain dosage effect.
【Fund】: 湖州市科技局重点项目(编号2005GN04)
【CateGory Index】: R285.5
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