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《Journal of Tea Science》 2006-03
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Research of FUZHUAN Tea’s Therapy for Hyperlipidemia by High-Throughput Screening

FU Dong-he,LIU Zhong-hua*,HUANG Jianan,GONG Yu-shun,CHEN Jin-hua(The Key Laboratory of Tea Science of National Ministry of Education,Changsha 410128,China)  
Searching high effective and natural medicines for therapy for hyperlipidemia is one of the focus of research.High-Throughput Screening is a kind of new technique of medicine screening.The water extractions of FUZHUAN Tea were extracted by chloroform,ethyl acetate,1-butanol separately.The samples were used to test their function of adjusting fat metabolism of FUZHUAN Tea by the models of PPARα,PPARγ,PPARδ,LXR,FXR and 3T3-L1 of High-Throughput Screening.The results showed that FUZHUAN Tea could activate PPARγ,PPARδ and restrain FXR.Its effect to PPRAα and 3T3-L1 was not obvious.FUZHUAN Tea was effective in therapy for hyperlipidemia.The active components need to be separated later.
【Fund】: 科技部十五重大科技攻关项目“茶叶与辣椒中功能成分高效提制技术研究与开发”(2004BA542C)
【CateGory Index】: TS272
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