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《Journal of Tea Science》 2006-03
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Effect of Interactions Between EGCG and Zn~(2+) on the Growth of Prostate Cancer PC-3 Cells

CHEN Xun1,YU Hai-ning2,SHEN Sheng-rong1(1.Institute of Tea Sciences,Zhejiang University,Hangzhou 310029,China;2.College of Pharmaceutical Sciences,Zhejiang University of Technology,Hangzhou 310032,China)  
In the present paper,effects of EGCG and interactions of EGCG with Zn2+on the growth of androgen-insensitive human prostate cancer cells(PC-3) were investigated by MTT assay.Effects of EGCG and Zn2+ on absorption of zinc and cadmium in PC-3 cells were detected by Flame Atomic Absorption Spectrometry(AAS) assay;and also the changes of Zn2+ on the partition coefficients of EGCG in n-octanol/PBS or n-octanol / water system were determined by HPLC technique.EGCG was screened for growth inhibition of PC-3 cells in dose-and time-dependent manners.Both Zn 2+ and EGCG decreased viability of PC-3 cells in dose-and time-dependent relations,and Zn2+ ameliorated the effect of EGCG on the growth of PC-3 cells.Also,Zn2+ decreased the absorption of PC-3 cells on Cd2+,and EGCG could enhance the effect as well.
【Fund】: 国家自然科学基金(30470198);; 博士后基金资助项目(2004036486)
【CateGory Index】: R737.25
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