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Research on the Anti-diabetes and Anti-hyperlipidenmia Function of Monomers in Pu-erh Tea

ZHANG Dong-ying1, SHAO Wan-fang1, LIU Zhong-hua2, LIU Ya-lin3, HUANG Ye-wei1 (1. College of Long Run Pu-erh Tea, Y N A U, Kunming 650201, China; 2. Tea Key Lab of the Ministry of National Teaching, HNAU, Changsha 410128, China; 3.Yunnan Agriculture Department, Kunming 650201, China)  
The anti-diabetes and anti-hyperlipidenmia function of Uracil and Gallic acid from Pu-erh Tea was studied by the PPARδ, PPARα, PPARγ, FXR, LXR, 3T3-L1 and α-amylase models which are related to glucose and lipid metabolism. Result showed that: Uracil and gallic acid were active to the models of PPARγ, FXR, LXR, especially, Gallic acid showed distinct active effect on PPARγ, the value was as high as 2.438 which showed the same effect as positive drug, and weak activity on PPARδ, PPARα, 3T3-L1 models. Gallic acid showed better activity than Uracil in the PPARγ model and Uracil showed better activity than gallic acid in the FXR and LXR models. Furthermore, Gallic acid showed strongth inhibition on the activity of α-amylase. It can provide some theoretical basis on the mechanism of Pu-erh tea on the anti-diabetes and anti-hyperlipidenmia activity.
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