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《Journal of Changchun University of Traditional Chinese Medicine》 2011-05
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Experimental study on acute toxicity and genetic toxicity of Agrimoni a pilosa Ledeb

LU Ying1,ZHANG Jie2(1.Yuelai Hospital of Haimen,Haimen,Jiangsu 226131;2.Nantong University,Nantong Jiangsu 226007)  
Agrimoni a pilosa Ledeb is a traditional Chinese herbal medicine,although it was listed as a food,the relative systematic toxicity and safety evaluation experiment was lacking.Methods:Systematic safety evaluation experiments were done using acute toxicity and genetic toxicity experiments including mice bone marrow micro-nuclear test.Results:LD50 was higher than 80 g/kg;no significant differences were observed in micronuclei rates.All toxicity tests were negative.Conclusion:It was found that Agrimoni a pilosa Ledeb didn't have mutagenic effects,agrimoni a pilosa Ledeb was a substance with low toxicity and has no genetic toxicity.
【CateGory Index】: R285.5
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