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《Journal of Changchun University of Traditional Chinese Medicine》 2014-06
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Protection effects of total flavonoids of propolis on cerebral ischemia and reperfusion of brain injury in rats

WANG Qihai;LIANG Feng;HOU Xi;Anhui Junior College of Traditional Chinese Medicine;  
Objective To explore the protection effect and mechanism of the total flavonoids of propolis( TFP) on the cerebral ischemia and reperfusion of brain injury in rats. Methods The 48 SD male rats of clean agent were randomly divided into sham operated group,model group,erigeron( 50 mg / kg) group,TFP low,middle and high dose( 25,50,100 mg / kg) groups. Pullsinelli- 4 vessel occlusion method was used by the model group and the drug group to prepare cerebral ischemia reperfusion injury model. The effects of TFP of low,middle and high dose on brain neural of rats with cerebral ischemia and reperfusion( NSS scores),cerebral ischemia area,activity of SOD and content of MDA in the brain were measured in each group. Results Compared to the sham operated group,the NSS scores,cerebral ischemia area,activity of SOD and content of MDA in the brain in the model group had statistical significance( P 0.01). Compared with the model group,TFP three dose groups can significantly decrease the NSS scores of rats with cerebral ischemia and reperfusion,which had statistical significance( P 0. 01). Compared with the model group,TFP middle and high dose group can obviously decrease the cerebral ischemic area and the content of MDA in the brain,which had statistical significance( P 0. 01). And compared with the model group,it can increase the activity of SOD,which also had statistical significance( P 0. 01). Conclusion TFP can significantly improve brain neural of rats with cerebral ischemia and reperfusion,decrease the cerebral ischemic area and the content of MDA in the brain,increase the activity of SOD and ease the impairment of cerebral ischemia and reperfusion on brain tissue of rats. It has a protective effect on the brain.
【Fund】: 安徽省高等学校省级优秀青年人才基金项目(2012SQRL273);; 安徽省高等学校省级质量工程项目专业(药学)综合改革试点项目(2012zy408)
【CateGory Index】: R285.5
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