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《Journal of Changzhi Medical College》 2006-03
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Changes of Endostatin and VEGF in Retina of Diabetic Rats and Protection of Tetromethylpragine on Them

Chen Haiying ,Liao Lihong , Chen Jianming Depat of Basic Medicine, Putian Universty,Putian,Fujian  
Objective:Inquiry into the big rat of diabetes sees the variety and ligustrazine that VEGF to suppress the vegetable with the surroundings skin inside the organization inside the retina blood vessel as to it's affect.Methods:Choose the big rat of the health adulthood SD, be divided into the normal control group(Ngroup),diabetec control group(DMgroup) and ligustrazine treat group(Tgroup).A sex belly cavity injects STZ to induct the diabetes model.The applied immunity organization chemistry method observes the expression circumstance that each one sees the retina organization VEGF, and examine the each organization in inside the skin suppresses the plain content variety. Results:Change along with the course of illness, the big rat of Diabetes sees the retina VEGF expression to strengthen, suppressing the plaincontent to increase inside the skin high;An ES of ligustrazine level is is always low in the diabetes set(P0.05).Conclusion:The rat of diabetes sees the excesssive expression of the retina VEGF and the variety of the content of endostatins to rise the important function in the occurrence development process that the diabetes sees the retina pathological changes( DR). The Ligustrazine ability feedback regulates the STZ rat blood vessel born repress the expression of the factor ES, promote DR repair.
【CateGory Index】: R774.1;R285
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