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《Journal of Changzhi Medical College》 2006-03
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Changes of Endostatin and VEGF in Retina of Diabetic Rats and Protection of Tetromethylpragine on Them

Chen Haiying ,Liao Lihong , Chen Jianming Depat of Basic Medicine, Putian Universty,Putian,Fujian  
Objective:Inquiry into the big rat of diabetes sees the variety and ligustrazine that VEGF to suppress the vegetable with the surroundings skin inside the organization inside the retina blood vessel as to it's affect.Methods:Choose the big rat of the health adulthood SD, be divided into the normal control group(Ngroup),diabetec control group(DMgroup) and ligustrazine treat group(Tgroup).A sex belly cavity injects STZ to induct the diabetes model.The applied immunity organization chemistry method observes the expression circumstance that each one sees the retina organization VEGF, and examine the each organization in inside the skin suppresses the plain content variety. Results:Change along with the course of illness, the big rat of Diabetes sees the retina VEGF expression to strengthen, suppressing the plaincontent to increase inside the skin high;An ES of ligustrazine level is is always low in the diabetes set(P0.05).Conclusion:The rat of diabetes sees the excesssive expression of the retina VEGF and the variety of the content of endostatins to rise the important function in the occurrence development process that the diabetes sees the retina pathological changes( DR). The Ligustrazine ability feedback regulates the STZ rat blood vessel born repress the expression of the factor ES, promote DR repair.
【CateGory Index】: R774.1;R285
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 CHEN Shao\|qiang, CHEN Rui\|hua, HUANG Yan, et al (Division of Anatomy and Histology and Embryology, Fujian Medical University, Fuzhou\ 350004, China) \ \;The Change of Vascular Endothelial Growth Factor and Nitric Oxide in the Retina of Diabetic Rats[J];Journal of Fujian Medical University;2002-03
【Co-citations】
Chinese Journal Full-text Database 2 Hits
1 CHEN Qun,LIU Jing-fengDepartment of General Surgery,The Affiliated First Hospital,Fujian Medical University,Fuzhou 350005,China;Changes and Significance of the Serum Nitric Oxide Level and NOS Activity in Diabetic Rats[J];Journal of Fujian Medical University;2005-04
2 LU Runxia,AN Jianhong,CHEN Jiangfan,et al.Hospital of Ophthalmology and Optometry,Wenzhou Medical College,Wenzhou China,325027;Effect of the A_(2A) adenosine receptor on the expression of vascular endothelial growth factor under high glucose conditions in human retinal pigment epithelium cells[J];Chinese Journal of Optometry & Ophthalmology;2009-05
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 FANG Jing,ZHANG Xue dong,LEI Chun tao,et al. (Department of Ophthalmology, the First Affiliated Hospital,Chongqing University of Medical Sciences, Chongqing 400016,China);Experimental study on tetramethylpyrazine(TMP) in the prevention and treatment of proliferative vitreoretionopathy[J];Chongqing Medical Journal;2004-01
2 CHEN Zhong-ping,JIANG De-yong,GUO Xiao-jiang,TANG Luo-sheng,ZHU Xiao-hua.Department of Ophthalmology,The Second Xiangya Hospital,Central South University,Changsha 410011,China;Effects of tetramethylpyrazine on the expression of nuclear factorkappa B induced by advanced glycation end products in retinal pigment epithelium[J];Journal of Chinese Physician;2006-05
3 SONG Zong Ming 1, CUI Shou Xin 2, ZHANG De Xiu 2 1Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, Xi'an 710033, China, 2First Hospital, Xi'an Jiaotong University, Xi'an 710061, China;Protective effects of TMP on the retinal ganglions and bipolar cells of rabbits with elevated intraocular pressure[J];Journal of The Fourth Military Medical University;2001-06
4 HUANG Yan, CHEN Shao\|qiang, CHEN Rui\|hua, et al (Department of Anatomy, Fujian Medical Uiniversity, Fuzhou\ 350004, China)\;;Protective Effect of Tetramethylprazine on the Free Radical Retinal Damage in Diabetic Rats[J];Journal of Fujian Medical University;2001-02
5 Chen Shaoqiang , Huang Yan, Chen Ruihua, Zhang Geng (Department of Anatomy, Fujian Medical University, Fuzhou 350004, China);EFFECT OF TREATMENT WITH TETROMETHYLPRAGINE AND AMINOGUANIDINE ON VEGF IN THE RETINA OF DIABETIC RATS[J];Chinese Journal of Histochemistry and Cytochemistry;2002-03
6 Juan Bu1, Jian-Jun Yang2,Jing Li1, Le-Jin Wang1,Wan-Rong Jin3 1 Peking University Eye Center, the Third Hospital, Beijing 100083, China; 2Department of Ophthalmology, the People Hospital of Lintao County, Lintao 750050, Gansu Province, China; 3Department of Ophthalmology, the Second Hospital of Lanzhou University, Lanzhou 730030, Gansu Province, China;Effect of ligustrazine on experimental ischemic retina diseases[J];International Journal of Ophthalmology;2009-02
7 LI Jin-xing1 ,JI Qiong-mei2, MA Ning-fang1 ,LIN Shu-bin1 ,HE Qing-hua1(1. Department of Histology and Embryology ;2. Department of Biochemistry,Guangzhou Medical College, Guangzhou ,510182);Effect of Tetramethylpyrazine on Apoptosis of Retinal Cells after Retinal Ischemia in Rats[J];Academic Journal of Guangzhou Medical College;2002-01
8 Long Qiaoyan Depantment of Ophthalmology, T.C.M Hospital of Conghua, Guangzhou 510900, China. Gao Zongyin, Department of Ophthalmolgy, the First Municipal People's Hospital of Guangzhou,510180 China;Effect of Puerarin injection treated for angle-closure glaucoma in the acute outbreak[J];Guangzhou Medical Journal;2003-03
9 JIANG Wan-song,ZHANG Kun,YANG Xiao-bo(Clinical laboratory,The 253rd Hospital of PLA,Huhhot 010051,China);Effects of Puerarin on Deformability and Aggregation of Human Erythrocytes[J];Medical Journal of National Defending Forces in North China;2006-01
10 DING You-mei,LEI Ya-ning(Department of pharmacology,Wenzhou Medical College,Wenzhou 325035,P.R.China);Protective effect of tetramethylprazine on retinal tissue of diabetic rats[J];Shandong Medical Journal;2006-29
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 HUANG Yan, CHEN Shao\|qiang, CHEN Rui\|hua, et al (Department of Anatomy, Fujian Medical Uiniversity, Fuzhou\ 350004, China)\;;Protective Effect of Tetramethylprazine on the Free Radical Retinal Damage in Diabetic Rats[J];Journal of Fujian Medical University;2001-02
2 Liu Xuezheng,Xiao Hong,Pang Dongbo,Li Ruixiang (Department of Anatomy,Jinzhou Medical College,Jinzhou 121001);ULTRASTRUCTURAL CHANGES OF RETINAL CAPILLARIES AND PHOTORECEPTORS IN EARLY DIABETIC RATS[J];Chinese Journal of Anatomy;2001-04
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