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The Experimental Study of DaChengQi Decoction Resisting Free-radical Damage

Guo Chunhua Lin xiuzhen Zhang Caili ChangZhi medical college(046000),  
In order to study the effect of DaChengQi decoction with protecting intracellular organelle,endotoxin was given to rabbits intravenously twice and produced generalized Shwartzman reaction(GSR).These animals were served as disseminated intravascular colagulation(DIC) model,serum and hepatic mitochondria lipid peroxides(LPO) were measured.The results showed LPO of DIC model group increased markedly than control group.Dexamethasone group was similar to control group,although DaChengQi decoction group was higher than control group they had no statistical difference(P0.05).Electronmicroscope result was in concordance with biochemical test.It indicate DaChengQi decoction can resist LPO damage induced by endotoxin and preserve intracellular organelle,reduce endotoxin injury to body.
【CateGory Index】: R285.5
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