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《Journal of Dalian University》 1991-01
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Study of Pharmacokinetics on Matrine

Luo Xueya Xia Bingnan  
The pharmacokinetic study of matrine was carried out by means of color- imetry.Matrine was injected intravenously into rabbits and the curve of blood concentration vs time was described by using an open two-compartment model. The pharmacokinetie parameters wre A,62.57 ug/ml;B,14.22ug/ml;α, 0.5045min~(-1);β,0.00905min~(-1);T_(1/2α),1.37min;T_(1/2β),76.58min;Cl,23.59 ml/min/kg;Vc,0.52L/kg;Vd,2.61L/kg.The content of matrine in rats' each tissue after administered orally was in turn the kidney,liver,lung,brain, heart and blood.Matrine was given orally to rats.The cumulative quantity of excretion of unchange drugs was 53.73% of the total dose in urine in 48h, 0.36% infeces in 24h and 0.27% in bile in 12h,while administered intraveno- usly to rabbits,was 9.39% of the total dose in urine and 0.37% in bile in 12h respectively.
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 Cha Li, Yang Zhehui, Zen Qinzuo Zhong Hennin Dep. of pharmacol;STUDY OF THE ANTIASTHMATIC MECHANISM OF SOPHORA FLAVENSERS[J];Journl of Guiyang Medical College;1985-03
【Co-citations】
Chinese Journal Full-text Database 6 Hits
1 WANG Yi MENG-GEN Da-lai ZHENG Wen-yan LIU Shuan-di (Department of Pharmacy, Affiliated Hospital, Inner Monglia Medical College, Huhohot 010050) (Department of Infection, 253st Hospital of PLA, Huhohot 010030);Pharmacokinetics of Oxymatrine Injection Healthy Volunteers[J];The Chinese Journal of Clinical Pharmacology;2003-04
2 WU Xiao-luan1, HANG Tai-jun1, SHEN Jian-ping2, ZHANG Yin-di2, XU Zhong-nan3, ZHANG Xi-lai3, ZHANG Lai-fang3 (1. Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China;2. Institute of Clinical Pharmacology, Nanjing Medical University, Nanjing 210029, China;3. Jiangsu Chia Tai-Tian Qing Pharmaceutical Co. Ltd., Lingyungang 223220, China);Pharmacokinetics of oxymatrine and its metabolite matrine in healthy volunteers after oral administration of oxymatrine capsule[J];The Chinese Journal of Clinical Pharmacology;2007-01
3 Luo Xueya, Xia Bingnan Department of Pharmacology;Pharmacokinctic Study of Matrine[J];Journl of Guiyang Medical College;1991-02
4 Ji Yong,Sun Lizhou, Rao Manren,et alDepartment of Cardiovascular Pharmacology,Nanjing Medical University, Nanjing 210029;The Relationship Between the Positively Inotropic Effect ofMatrine and the Cytosolic Free Calcium Concentration[J];ACTA ACADEMIAE MEDICINAE NANJING;1998-04
5 ZHAO Zi-qian ( Fengheying Middle Shool of CaiYu town, Daxing district, Beijing 102608 China) DIAO Zhi-min,XIONG Ya (The ecology institute of Qing-Tibetan Plateau, Qinghai Normal University, Xining Qinghai 810008,China);THE DEVELOPMENTAL SITUATION AND APPLICATION POTENTIAL OF SOPHARA ALOPECUROIDES L.IN THE PASTORAL AREA OF QINGHAI[J];Qinghai Prataculture;2004-04
6 DU Song,DENG Ying-jie,LIANG Wei(School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China);Physicochemical properties study of oxymatrine[J];Journal of Shenyang Pharmaceutical University;2006-02
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