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《Journal of Dalian University》 2001-02
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Correlation Between Serum Level of Cytokines and Inflammation as Well as Pathology in Adjuvant Arthritis in Rats

WU Lan, et al (Medical College of Dalian University. Dalian 116622, China)  
Objective To document the role of cytokines in rhrumatoid arthritis. Methods Fifty SD rats were injected Complete Freund's adjuvant to produce adjuvant arthritis (AA). All rats were divided into groups randomly according to different disease phases. Group(G) Ⅰ (week2), GⅡ (week3), GⅢ (week4), GⅣ (week8) and GⅤ (normal control). Different parameters include serum level of proinflammatory cytokine TNF-α and IL-6, inhibit cytokine IL-4 and IL-10, inflammatory makers ESR, joint swelling rate, pathologic exmination were obtained and analyzed dynamically. Results Inflammatory makers including ESR, joint swelling rate were singificantly different between the AA rats and controls (p0.01); Level of TNF-α in GⅠ-GⅣ were higher than normal controls (P0.05, p0.01, P0.001, aspectively); IL-6 level was high in group GⅡ (P0.05) and GⅢ than normal; IL-4 level in group GⅠ and GⅡ were lower than normal and higher in GⅢ and GⅣ, but no statistics significance; IL-10 level were lower in GⅠ, (P0.01) GⅡ (P0.05), and GⅢ, but high in GⅣ (p0.01); Dynamic observation showed that TNF-αa and IL- 6 leves went up with acute phase (2W) of AA and down with chronic phase (8W). The levels of IL-4 and IL-10 went up after inflammatory cytokines and the peak of levels was at the chronic phase when the levels of inflammatory cytokine went down. Conclusions In AA rat model, TNF-α, IL-6 were positively correlated with ESR, joint swelling rate and pathological changes while IL-4 and IL-10 were negatively correlated with inflammation.
【CateGory Index】: R363
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