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《Journal of Northeast Agricultural University》 1989-03
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STUDY ON THE PHARMACOKINETIC CHARACTERISTICS OF CEPHALOTHIN I IN HORSES

Tong Hengmin, Qiao Guilin, wang Zhenlong and Li Tao (Northeast Agricultural College, Harbin, China)  
A high—performance Liquid chromatography (HPLC) procedure was used to determine cephalothin kinetics in four healthy adult horses. The HPLC was performed with a reversed—phase Zorbax ODS column[25mm×4.6mm~2(ID)]. The column temperatures was 35℃, The mobile phase consisted of methanol: water: 36%acetic acid: 1.77% phosphate buffer. The flow rate was 0.8ml/min. A wavelength of UV detector operated at 245nm.Cephalothin concentration in plasma at different time was determined by HPLC.The data of drug concentration-timefi tted to two-compartment open model and their calculation were performedr by sharp PC—1500 pocket computer.Their pharmacokinetic parameters of cephalothin were described as follows: Biological half-life(tl/2β)of the drug was 0.50±0.15(hr), the distribution half—life(t1/2α) of the drug was 0.05±0.01 (hr), the area under curve (AUC)was 49.122±29.01(μg/ml.hr), the apparent volume of distribution (V_d) was 0.305±0.1488 (L/kg), the total body clearance(CIB) was 0.3877±0.1418 (ml/kg·hr),tcp (ther) was 2.78±0.49 (hr).The parameters of multiple dose administration were calculated as follows:The intervals of adminisrtation for multiple dose of the drug (τ) were 4 (hr), the accumulation factor (R) was 1.00, the maximum [(C∞)max], average(C) and minimum[(C∞)min] plateau plasma concentration were 223.99(μg/ml) 12.28(μg/ml)and 0.06 (μg/ml) respectively, the loading dose (D_0~*) was 15.00 (mg/kg).
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【Co-citations】
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1 MOULing WANLang-Ping JIBu-qing(Linyi Tumor Hospital, Shandon276000)[;A STUDY ON PKEVENTIVE EFFECT OF SULPIRIDE TO NAUSEA AND VOMITING CAUSED BY Non-CISPLATIN CHEMOTHERAPY[J];CHINESE JOURNAL OF CANCER;1995-06
2 Zhang Xiaomei(Department of Chemistry);Determination of Chlofenamic acid and Flufenamic acid by Ac Oscillopolarographic Titration Method[J];;1998-01
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4 Hao Manliang (College of Animal Science and Technology,Agri. Univ. of Hebei,Baoding 071001);Researchs on Reliability of Tabellae Sulfamethoxazoli Compositae for Chicken[J];Journal of Agricultural University of Hebei;1997-02
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8 Zheng Yan, et al(Department of Pharmacology);EXPERIMENTAL OBSERVATIONS ON PROPHYLAXIS OF BUPIVACAINE INTOXICATION[J];Journal of The Fourth Military Medical University;1985-02
9 Zhu Daling, et al Heilungkiang Institute for Endemic Diseases Control and Research;COMPARATIVE STUDY ON THE CHANGE OF AMINO ACID PROFILE OF URINE AMONG THE THREITOL LEAD ACETATE THALLIUM SUFATE AND SUFOUREA[J];Chinese Journal of Control of Endemic Disease;1992-03
10 Li Xiurong;Reasonable use of Medicine,Improvement of Curatire Effect[J];Journal of Huaibei Industry Teachers College (Natural Sciences Edition);1994-03
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