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《Journal of Eastern Liaoning University(Natural Science)》 2010-02
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Synthesis of 2-Br-2methyl-1-(N-methyl-1-piperazine)-1-acetone

GONG Sheng-chen,CHEN Qi-fan,QU Zheng(Experimental Center,Eastern Liaoning University,Dandong 118003,China)  
2-Br-2-methyl-1-(N-methyl-1-piperazine)-1-acetone was synthesized by N-acylation reaction of N-methyl piperazine and 2-Br-2-methyl-propionyl chloride which was synthesized by reacting dichloro sulfoxides with 2-Br-2-methyl-propionic acid.The optimum reaction conditions are as follows: the ratio of raw materials of N-methyl piperazine and 2-Br-2-methyl-propionyl chloride was 1:1;the reaction temperature was 12 ℃;the reaction was 4 h;the reaction medium was mixture of water and ethyl acetate.Under the optimal condition,the highest yield of the object compound was 79%.The synthetic product was purified through re-crystallization.And the structure of the product was characterized by TR and 1HNMR.
【CateGory Index】: TQ253
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