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《The Chinese Journal of Contemporary Pediatrics》 2004-05
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Expression of Survivin and Caspase-3 mRNA in Wilms tumor

Hong GAO, Chang-Lin WANG, Wei-Song CAI, Bei-Bei ZHU. Major Laboratory of Health Ministry in Congenital Malformations, Second Affiliated Hospital, China Medical University, Shenyang 110004, China  
Objective Abnormal expression of Survivin has been found in the majority of tumor tissues and it can directly inhibit the expression of Caspase-3. It is suggested that Survivin plays an important role in the development of tumors. This study aims to investigate the expression of Survivin and Caspase-3 mRNA in Wilms tumor. Methods Survivin and Caspase-3 mRNA were detected by RT-PCR in 48 specimens from Wilms tumor tissues and 24 from adjacent normal kidney tissues. Results Survivin mRNA was expressed in 72.9% of Wilms tumor tissue samples, while no Survivin mRNA expression was detected in adjacent normal kidney tissues. In contrast, Caspase-3 mRNA was expressed in only 8.3% of Wilms tumor tissues but 45.8% of adjacent normal kidney samples (P 0.05). Conclusions Increased expressions of Survivin mRNA and decreased expression of Caspase-3 mRNA were found in Wilms tumor, and may be related to the development of Wilms tumor.
【CateGory Index】: R737.11
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