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《The Chinese Journal of Contemporary Pediatrics》 2004-05
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Expression of Survivin and Caspase-3 mRNA in Wilms tumor

Hong GAO, Chang-Lin WANG, Wei-Song CAI, Bei-Bei ZHU. Major Laboratory of Health Ministry in Congenital Malformations, Second Affiliated Hospital, China Medical University, Shenyang 110004, China  
Objective Abnormal expression of Survivin has been found in the majority of tumor tissues and it can directly inhibit the expression of Caspase-3. It is suggested that Survivin plays an important role in the development of tumors. This study aims to investigate the expression of Survivin and Caspase-3 mRNA in Wilms tumor. Methods Survivin and Caspase-3 mRNA were detected by RT-PCR in 48 specimens from Wilms tumor tissues and 24 from adjacent normal kidney tissues. Results Survivin mRNA was expressed in 72.9% of Wilms tumor tissue samples, while no Survivin mRNA expression was detected in adjacent normal kidney tissues. In contrast, Caspase-3 mRNA was expressed in only 8.3% of Wilms tumor tissues but 45.8% of adjacent normal kidney samples (P 0.05). Conclusions Increased expressions of Survivin mRNA and decreased expression of Caspase-3 mRNA were found in Wilms tumor, and may be related to the development of Wilms tumor.
【CateGory Index】: R737.11
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Chinese Journal Full-text Database 3 Hits
1 ZHU Yong-Sheng,GUO Xiang,GE Juan.Second Affiliated Hospital of Nanjing Medical University,Nanjing 210011,China;Induction of apoptosis and inhibition of HL-60 cell proliferation by survivin antisense oligonucleotide[J];Chinese Journal of Contemporary Pediatrics;2006-02
2 HOU Yan,HU Qun,LIU Ai-Guo,ZHANG Liu-Qing,LIU Shuang-You.Research Laboratory of Pediatric Hematology,Tongji Hosipital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Expression of survivin and its location in bone marrow cells of childhood acute leukemia: relationship to therapeutic efficacy[J];Chinese Journal of Contemporary Pediatrics;2006-02
3 NIU Zhi-bin WANG Chang-lin HOU Ying YANG Yi GAO Hong Department of Pediatric Surgery,Shengjing Hospital,China Medical University,Shenyang 110004,China;Expressions of survivin and VEGF in Wilms'tumor[J];Chinese Journal of Pediatric Surgery;2007-09
Chinese Journal Full-text Database 2 Hits
1 CHANG Qing,QIN Ren yi,QIU Fa zu.Department of Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Survivin expression in cholangiocarcinoma[J];Chinese Journal of Experimental Surgery;2003-05
2 LIN Maofang, MENG Xiaoli, CAI Zhen, YE Xiujin. Department of Hematology, the First Affiliated Hospital of Medical College, Zhejiang University, Hangzhou 310003, China;Expression and clinical significance of anti-apoptosis gene, survivin, in acute leukemia[J];Chinese Journal of Hematology;2002-05
Chinese Journal Full-text Database 10 Hits
1 LIU JIAN-GANG,GUAN HONG-ZAI,LU WEI (Department of Hematology,Qingdao University Medical College,Qingdao 266021,China);CLINICAL SIGNIFICANCE OF SURVIVIN EXPRESSION IN ACUTE LEUKEMIC CELLS[J];Acta Academiae Medicinae Qingdao Universitatis;2007-04
2 LI Zhong-dong, QI Zhen-hua,WANG Guang-ping. Department of Hematology, Xiangya Hospital, Central South University, Changsha 410008, China;Expression and Clinical Significance of Survivin in Acute Leukemia[J];Journal of Chinese Physician;2004-01
3 GUAN Xian-min,XU You-hua(Department of Hematology,Children's Hospital,Chongqing University of Medical Sciences,Chongqing 400014,China);Expression and clinical value of surviving in mononuclear cells of bone marrow and peripheral blood of children with acute leukemia[J];Acta Academiae Medicinae Militaris Tertiae;2005-22
4 Wang Yan1,Sun Ling1,Zhao Guoqiang2,Wang Yesheng1(1.Department of Hematology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;2.Department of Microbiology and Immunology,College of Basic Medical Sciences,Zhengzhou University,Zhengzhou 450052,China);The Inhibitory Effect of Survivin Expression Vector of Leukemia Cell Line HL-60 by RNAi[J];Journal of Basic and Clinical Oncology;2007-03
5 MENG Xiaoli Department of Hematology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052;Relationship between expression of survivin gene in primary leukemic cells and apoptosis induced by chemotherapeutic agents[J];Journal of Zhengzhou University(Science Medical);2005-01
6 MENG Xiaoli Department of Hematology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052;Sensitivity of survivin-positive primary acute leukemia cells to aclacinomycin and cytarabine[J];Journal of Zhengzhou University(Medical Sciences);2006-06
7 SHEN Yue-di,CHEN Yu(1.Medical College of Hangzhou Teachers College,Hangzhou,Zhejiang 310036,China;2.The Affiliated Hospital of HangZhou Teachers College,Hangzhou,Zhejiang 310015,China);The study on survivin expression in myeloid tissue of patients with acute leukemia[J];Journal of Hangzhou Normal University(Medical Edition);2007-01
8 LI Zhongdong,QI Zhenhua,CAO Xingyu,et al. Department of Hematology, XiangYa Hospital,Central South University,ChangSha 410008,China;The correlation of survivin gene expression with drug resistance in acute leukemia patients[J];Journal of Clinical Internal Medicine;2004-03
9 LIN Fengru 1 WANG Ying 1 WANG Rongqi 1 DU Xingyan 1 GUO Xiaonan 1 REN Jinhai 1 GUO Xiaoling 1 YAO Li 1 YAO Ergu 1 ( 1Department of Hematology,the Second Affiliated Hospital, Hebei Medical University ,Shijiazhuang 050000,China);Clinical significance of survivin, multidrug resistance and lung resistance protein gene expression in acute myeloid leukemia[J];Journal of Clinical Hematology;2003-02
10 LIU Yuan-sheng~1, ZENG Yu-ran~1, ZHANG Dong-qing~1, ZENG Si-min~2,CAI Ying-mu~2,SU Yong-zhong~1,CHEN Fei-heng~1(1 Department of Hematology,The First Affiliated Hospital,Shantou University Medical College,Shantou 515041,China;2 Department of Clinical Laboratory,The First Affiliated Hospital,Shantou University Medical College,Shantou 515041,China);The Expression of Survivin and Its Relationship with Apoptosis and Proliferation in Acute Leukemia Cells[J];Journal of Shantou University Medical College;2005-02
Chinese Journal Full-text Database 10 Hits
1 MENG Zhi qiang, SONG Ming zhi, HUANG Wen xia, et al Department Hepatology,Cancer Hospital of Shanghai Medical University,Shanghai 200032,P R China;The effects of different drugs on telomerase activity of liver cancer cell[J];CHINESE JOURNAL OF CANCER;2000-04
2 MA Jing1, FU Nai yang2, LI Yu mei3, PENG Wen lie1, XU An long1*1.Department of Biochemistry and Center for Biopharmaceutical Research, College of Life Science, Zhongshan University, Guangzhou 510275, P.R.China2.Institute for Drug Control of Guangdong;Glycyrrhiza uralensis Fisch Extract Selectively Induces Apoptosis in Several Human Cancer Cell Lines in Vitro[J];Chinese Journal of Cancer;2001-08
3 Yang Dong, Zhu You-Qing, Qi Jian Department of Digestion, Zhongnan Hospital of Wuhan University, Wuhan,Hubei,430071, P.R.China;Expression and Clinical Significance of Survivin Gene and PTEN Protein in Colorectal Adenocarcinoma[J];Chinese Journal of Cancer;2004-03
4 YNAG Xiao-huai1,LI Qing-wen1,ZHANG Jia-jun1,CHENG Ze-nong2(1.Department of Urology,Affiliated Hospital of Medical College,Bengbu 233004;2.Department of Pathology,Bengbu Medical College,Bengbu 233003,China);Expression of Caspase-3 in bladder transitional carcinoma and its significance[J];Journal of Bengbu Medical College;2005-04
5 ZHANG Man ying,AN Ji hong,LI Chang hui (Dept.of Respiration,The Second Hospita,Jilin University,Changchun 130021 China);Study on apoptosis of Spc-A_1 cell induced by acanthophopanax senticosus[J];Journal of Norman Bethune University of Medical Science;2002-01
6 YI Cheng-la,CHEN An min,XU Wei guo,et al. (Department of Orthopedics,Tongji hospitol,Tongji Medical College,Huazhong University of Science and Techology,Wuhan 430030,China);Study of correlation between Caspase-3 expression and neural cell apoptosis after spinal cord injury in rats[J];Journal of Traumatic Surgery;2004-03
7 CHEN Wei Zhong 1, LIN Yong 1, XIE Wei Fen 1, ZHANG Jun Ping 2, ZHANG Xin 3, CHENG Zhi Hong 3 (1. Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China; 2.Department of Pharmacology, Colle;Regulation of telomerase activity and cell cycle by matrine in hepatoma cells in vitro[J];Academic Journal of Second Military Medical University;2002-05
8 XU Qiang, SI Liang yi, ZHAO Xiao lan, WANG Zhang (Department of Gerontology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China);Changes of apoptosis and caspase-3 activity and the effects of Ac-DEVD-CHO in cardiomyocytes of rats with myocardial reperfusion injury[J];Acta Academiae Medicinae Militaris Tertiae;2003-15
9 ZHOU Zhou, WANG Xiao-hua, ZHU Guang-xu, YU Zheng-ping (Department of Occupational Health, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China);Up-regulation of caspase-3, -9 expressions participates in hypoxia-induced cardiomyocyte apoptosis[J];Acta Academiae Medicinae Militaris Tertiae;2005-03
10 LU Xiao Ying 1, ZENG Lin Fu 2, ZHENG Bao Chun 1, LIU Xin Hua 1, ZHENG Ke Qin 1 1Institute of Military Medical Sciences of Chengdu Military Command, Kunming 650032, China, 2Department of Nutrition & Food Health, West China Universit;Inducing apoptosis effects of acanthopanax giraldii harms var hispidus hoo polysaccharides on gastric cancer cells[J];Journal of The Fourth Military Medical University;2000-11
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