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《Contemporary Medicine》 2009-09
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Objective To investigate the protective effects of cholecystokinin octapeptide(CCK-8) on lung ischemia-reperfusion injury in rats and its possible mechanisms.Methods Thirty healthy male wistar rats were randomly divided into three groups: surgical controls(C group),ischemia-reperfusion group(IR group) and CCK-8 pretreated group(K group).After 120m in reperfusion every 10 rats from the groups were sacrificed,collected for plasma sample and the whole right lung.The plasma contents of malondialdehyde(MDA) and activity of superoxide dismutase(SOD) in plasma,the wet/dry(W/D) weight ratio and the activity of myeloperoxidase(MPO),Histopathological study of the lung tissue was also performed.Results The plasma contents of MDA,the W/D weight ratio and MPO activity in lung tissue were all signifi cantly increased during reperfusion in IR group,while the activity of SOD in plasma were lower than other groups.Pretreamented by CCK-8,can attenuate the abnormal changes by IR induced.Pathological examination showed that the IR induced injury was also ameliorated by CCK-8 pretreament.Conclusion CCK-8 treatment before ischemia appeared to protect the lungs against IR induced injury,possibly by inhibited PMN infi ltration and reduced production of oxygen radicals.
【Fund】: 山西省卫生厅科技攻关基金资助项目(200608)
【CateGory Index】: R563
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