Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Contemporary Medicine》 2009-09
Add to Favorite Get Latest Update

八肽胆囊收缩素对大鼠肺缺血再灌注损伤的保护作用

Objective To investigate the protective effects of cholecystokinin octapeptide(CCK-8) on lung ischemia-reperfusion injury in rats and its possible mechanisms.Methods Thirty healthy male wistar rats were randomly divided into three groups: surgical controls(C group),ischemia-reperfusion group(IR group) and CCK-8 pretreated group(K group).After 120m in reperfusion every 10 rats from the groups were sacrificed,collected for plasma sample and the whole right lung.The plasma contents of malondialdehyde(MDA) and activity of superoxide dismutase(SOD) in plasma,the wet/dry(W/D) weight ratio and the activity of myeloperoxidase(MPO),Histopathological study of the lung tissue was also performed.Results The plasma contents of MDA,the W/D weight ratio and MPO activity in lung tissue were all signifi cantly increased during reperfusion in IR group,while the activity of SOD in plasma were lower than other groups.Pretreamented by CCK-8,can attenuate the abnormal changes by IR induced.Pathological examination showed that the IR induced injury was also ameliorated by CCK-8 pretreament.Conclusion CCK-8 treatment before ischemia appeared to protect the lungs against IR induced injury,possibly by inhibited PMN infi ltration and reduced production of oxygen radicals.
【Fund】: 山西省卫生厅科技攻关基金资助项目(200608)
【CateGory Index】: R563
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 2 Hits
1 GU Zhen Yong (Department of Pathophysiology, Hebei Medical University, [WT5”BZ]Shijiazhuang 050017) [WT5HZ];Peroxynitrite-Mediated Pulmonary Vascular Injury Induced by Endotoxin and the Protective Role of Cholecystokinin[J];Progress In Physiological Sciences;2001-02
2 TIAN Feng-jun,LING Yi-ling,HUANG Xin-li,WEI Peng,ZHOU Xiao-hong(Department of Pathophysiology,Hebei Medical University,Shijiazhuang 050017,China.);Protective role of endogenous hydrogen sulfide in cholecystokinin octapeptid against acute lung injury induced by lipopolysaccharide[J];Chinese Journal of Pathophysiology;2007-04
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LING Yi-ling,HUANG Xin-li(Department of Pathophysiology,Hebei Medical University,Shijiazhuang 050017,China);Importance of the role of endogenous anti-shock material in shock[J];Journal of Traumatic Surgery;2008-03
2 Li Jianqiang,Jing Junhu,Zhao Hui,Liu Zhuola(Department of Respiratory Disease,The Second Hospital of Shanxi Medical University,Taiyuan 030001,China);A STUDY OF THE PROTECTIVE EFFECTS OF BILIRUBIN ON ISCHEMIA-REPERFUSION INJURY IN RAT LUNG[J];Chinese Journal of Histochemistry and Cytochemistry;2008-03
3 GU Zhen Yong, LING Yi Ling , LI Shu Jin, MENG Ai Hong, ZHANG Jun Lan (Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017);Properties of peroxynitrite-induced relaxation in rabbit pulmonary artery in vitro[J];Acta Physiological Sinica;2001-04
4 ZHANG Zhao-jian,LI Zhi-jun(Tianjin University of Chinese Medicine,Tianjin,300193,China);Clinical Observation of Treating Both Lung and Intestine on Acute Exacerbation of Chronic Obstructive Pulmonary Disease[J];Shanxi Journal of Traditional Chinese Medicine;2009-10
5 Yu Xiaohua,Zhang Ping,Li Jianzhi(Nurse school of Nanhua University,Hengyang 421001,Hunan,China);Protective effects of astragaloside on ischemia reperfusion-induced lung injury in rats[J];Modern Journal of Integrated Traditional Chinese and Western Medicine;2008-33
6 ZHAO Hui, JING Jun-hu, LI Jian-qiang, LIU Zhuo-la. Department of Respiratory, Second Affiliated Hospital of Shanxi Medical University, Taiyuan 030001,China;The anti-apoptotic role of bilirubin in ischemia-reperfusion injury of rat lungs[J];Chinese Remedies & Clinics;2007-09
7 LIU Bing, ZHAO Hui, NIU Pan-xia, LI Jian-qiang.Department of Respiratory Medicine, Second Hospital of Shanxi Medical University, Taiyuan 030001, China;Protective effects of adriamycin against lung ischemia-reperfusion injury in rats[J];Chinese Remedies & Clinics;2009-05
8 YANG Shi-fang, LING Yi-ling, DAI Hong-yan, et al. (Department of Pathophysiology, Hebei Medical University,Shijiazhuang 050017,China);Regulation of cholecystokinin octapeptide on nitric oxide level in brain cortex in normal or brain ischemia rats[J];Journal of Apoplexy and Nervous Diseases;2003-02
9 LIANG Jun-qing,DING Chun-hua,LING Yi-ling,XU Hai-bo,LU-ping,XIAN Xiao-hui(Department of Pathophysiology of Hebei Medical University,Shijiazhuang 050017,China);THE PROTECTIVE FUNCTION OF PUERARIN TO THE INJURY OF THE LUNG AND IT'S MECHANISMS DURING DIABETES[J];Chinese Journal of Applied Physiology;2007-03
10 GAO Ju, ZENG Bang-xiong. Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China;Protective effects of prophylactic propofol on the lungs against acute injury induced by endotoxin in rats[J];Chinese Journal of Anesthesiology;2004-06
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 DU Jun Bao 1, CHEN Xiao Bo 1, GENG Bin 2, JIANG Hong Feng 2, TANG Chao Shu 2 (1. Department of Pediatrics; 2.Institute of Cardiovascular Diseases, Peking University First Hospital, Beijing 100034, China);Hydrogen sulfide as a messenger molecule in cardiovascular system[J];Journal of Beijing Medical University;2002-02
2 Xiang Mingzheng,et al. Department of Thoracic Surgery, (The Xinqiao Hospital of Third Militarty medical University, Chongqing 400037);The Changes of TNF_α,IL-6 and IL-8 in Lung and Plasma in Rats With Lung Ischemia-reperfusion Injury and Their Singificances[J];CHONGQING MEDICAL JOURNAL;1999-01
3 Guo Zheng hui, Hong Xin, Mao Bao ling, QIAN Gui sheng, CHEN Zheng tang (Institute of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing 400037,China);Effects of anisodamine on the expression of TNFα and IL-8 in pulmonary tissue of rats with LPS induced acute lung injury[J];ACTA ACADEMIAE MEDICINE MILITARIS TERTIAE;2000-05
4 WEI Peng,ZHOU Xiao-hong,LING Yi-qun,DAI Hong-yan,HUANG Xin-li,LING Yi-ling~* (Department of Pathophysiology,Hebei Medical University,Shijiazhuang 050017,China);Role of hydrogen sulfide in acute lung injury induced by lipopolysaccharide in rats[J];Basic & Clinical Medicine;2006-03
5 LING YI-LING AND SHAN-SHENG(Institute of Basic Medicine,Hebei Medical University,Shijiazhuang 050017)WANG LE-FENG,ZHANG JUN-LAN WAN MEI AND HAO RONG-LI;CHOLECYSTOKININ-OCTAPEPTIDE (CCK-8)REVERSES EXPERIMENTAL ENDOTOXIN SHOCK[J];ACTA PHYSIOLOGICA SINICA;1996-04
6 ZHANG Chunyu, DU Junbao, YAN Hui, et al. Pediatric Department,Peking University First Hospital,Beijing 100034, P.R.China;The regulatory effect of hydrogen sulfide on hypoxic pulmonary hypertension[J];Journal of Applied Clinical Pediatrics;2003-02
7 LI Shu-jin~1, YAO Yu-xia~1, ZHU Gui-jun~2, LING Yi-ling~1, CONG Bin~1(~1Department of Pathophysiology, Hebei Medical University,?~2?Department of ICU, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050017, China);Cholecystokinin octapeptide inhibits tumor necrosis factor-α transcription and nuclear factor-κB activity induced by lipopolysaccharide in rat pulmonary interstitial macrophages[J];Chinese Journal of Pathophysiology;2004-08
8 HUANG Xin-li, ZHOU Xiao-hong, LING Yi-ling, DAI Hong-yan, ZHANG Xiao-jing (Department of Pathophysiology, Hebei Medical University , Shijiazhuang 050017, China);Role of carbon monoxide in CCK-8 ameliorating acute lung injury induced by LPS[J];Chinese Journal of Pathophysiology;2005-11
9 ZHOU Xiao-hong, WEI Peng, LING Yi-qun, DAI Hong-yan, HUANG Xin-li, LING Yi-ling (Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017, China);Effect of endogenous H_2S on pulmonary hypertension during acute lung injury induced by LPS and its interaction with NO[J];Chinese Journal of Pathophysiology;2006-04
10 LIANG Ji he, ZHU Yun xi, LI Qi, et al. Dept. of Cardiothoracic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032;Experimental Study of Preventive and Therapeutic Effects of Anisodamine on Traumatic Acute Lung Injury[J];CHINESE JOURNAL OF TRAUMATOLOGY;1998-05
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved