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《Contemporary Medicine》 2009-23
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Clinical Study of P53 intratumoral injection in the treatment of Hepatocellular Carcinoma

ZHANG Bai-qiu,SUN Yi-xing,SUN Peng,ZHENG Chang-sheng,XU Ji-yi,ZUO Shu-jie Department of Interventional Radiology Chang chun Central City Hospital,Jinlin,130051 China  
Objective: To compare the p53 gene injection of combined transcatheter arterial chemoembolization (GTACE) and conventional hepatic arterial chemoembolization (TACE) in the treatment of short-term efficacy of the terminal stages of primary liver cancer. Methods: use GTACE (16 cases) and conventional treatment of TACE (19 patients) in treatment to patients who are suffering inoperable advanced liver cancer. Group first GTACE artery embolization by tumor vascular cast until a week after the color Doppler ultrasound-guided percutaneous puncture of liver tumors in vivo by multi-point injection of p53 gene,once a week,4 times as a course of treatment. Till the TACE artery reach the blood vessels through the blood-supply artery of the embolization of the tumor. Both of the two groups will be dealt with by the liver and illness after treatment. Clinical Observation of follow-up score card indicators,the recent living condition of the patients,imaging follow-up and the degree of the shrinkage of the tumor. Results: the differences within Karnofsky group before and after the GTACE treatement is of statistically significance (p 0.05). The living condition of the patients (the comparison between two groups of patients was of statistically significance p 0.05). After imaging follow-up ,the size of tumor lesions of the two groups’ people have narrowed,and group differences were statistically significant (p 0.05). Conclusions: to the advanced liver cancer patients who cannot suffer the surgery,GTACE compared with TACE alone in patients with survival time,the patient quality of life (K's score) to reduce the rate of tumor has a distinct advantage. However,the exact long-term efficacy also requires large samples and long-term multi-center randomized controlled study to prove.
【Fund】: 吉林省科技厅资金资助项目编号:20050405-6
【CateGory Index】: R735.7
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