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《Contemporary Medicine》 2012-19
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复方绞股蓝益智颗粒急性毒性与慢性毒性实验研究

Objective In this paper, to investigate the safety of CJG to provide theoretical support and safety assurance for its clinical and general applications as CJG is a new generation of safe and healthy food. Methods In the acute toxicological test, the mice received orally by gavage the maximum tolerated oral dose of CJG of more than 30000 mg·kg-1·d-1, and clinical symptoms and survival for 14 days post administration were observed. In subchronic toxicological test, rats received by gavage of doses of 3333 mg·kg-1·d-1, 5000 mg·kg-1·d-1, 6667 mg·kg-1·d-1 of CJG for 30 days for observing CJG’s effects on growth and development, abnormal hematological, biochemical, and histopathological changes. Results In the acute toxicity test, no death or clinical signs were found in mice. In the subchronic study, no death or clinical signs, or abnormal hematological, biochemical and histopathological changes were found in rats after receiving, by gavage 3333 mg·kg-1·d-1, 5000 mg·kg-1·d-1, 6667 mg·kg-1·d-1 of CJG for 30 days. Conclusion The results of the toxicology test indicated that CJG may be safely used as a health food.
【Fund】: 广西科学研究与技术开发计划项目(桂科合1140010-4);; 第19次中泰科技合作联委会项目(19-509J;19-521J)
【CateGory Index】: R114
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【Citations】
Chinese Journal Full-text Database 4 Hits
1 ;丙烯酰胺安全性毒理学评价[J];Contemporary Medicine;2009-18
2 ZHONG Zhen-guo,QU Ze-qiang,BAO Yun-ping,WANG Nai-ping,ZHANG Feng-fen,ZHANG Wen-yan(Guangxi University of Chinese Medicine,Guangxi 530001);Influence of PNS on abilities of space search,learning and memory in rats with Alzheimer's disease[J];Journal of Beijing University of Traditional Chinese Medicine;2006-01
3 DENG Jia-gang,HAO Er-wei,GUO Hong-wei,LIU Jun-hui(Guangxi University of TCM,Nanning 530001,China);Analysis of drug law of compound prescription in treating Alzheimer disease[J];Shandong Journal of Traditional Chinese Medicine;2007-06
4 Deng Jiagang,Du Zhengcai,Hao ErweiGuangxi Traditional Chinese Medical University,Nanning Guangxi 530001;Effect of Compound Jiao Gu Lan Medicines on Memory and Brain Monoamine Oxidase Activity of Mice[J];World Journal of Integrated Traditional and Western Medicine;2007-12
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LI Qiang1,CUI Yuan-wu2,ZHANG Yu-lian2(1.Tianjin University of Traditional Chinese Medicine Tianjin 300073,China; 2.Second Affiliated Hospital,Tianjin University of Traditional Chinese Medicine,Tianjin 300073,China);Literature Analysis on Traditional Chinese Medicine for Treating Alzheimer′s Disease[J];Liaoning Journal of Traditional Chinese Medicine;2012-07
2 ZHANG Zhong;WANG Shu-yan;HONG Qing-tao;SI Yin-chu;BAI Li-min;Department of Human Morphology,School of Preclinical Medicine,Beijing University of Chinese Medicine;;Influences of disassemble formulas of Yizhi Fang with different combinations on peroxiation and apoptosis of neurons induced by Aβ_(25-35) in rats[J];Journal of Beijing University of Traditional Chinese Medicine;2013-09
3 Deng Jiagang,Du Zhengcai,Hao ErweiGuangxi Traditional Chinese Medical University,Nanning Guangxi 530001;Effect of Compound Jiao Gu Lan Medicines on Memory and Brain Monoamine Oxidase Activity of Mice[J];World Journal of Integrated Traditional and Western Medicine;2007-12
4 XU Xian-xiang,WU Yang-zheng(Institute of Molecular Medicine,Huaqiao University,Quanzhou 362021,China);Review of delaying senility effects of saponins[J];Science and Technology of Food Industry;2012-11
5 CHEN Chao-jie1,2,ZHANG Wen-sheng1,2(1.Beijing Area Major Laboratory of Protection and Utilization of Traditional Chinese Medicine,Beijing 100875,China;2.Institute of Natural Medicine and Chinese Medicinal Resources,College of Resource Science & Technology,BNU,Beijing 100875,China);Research Progress on the Treatment to Alzheimer's Disease with Panax Notoginseng[J];Lishizhen Medicine and Materia Medica Research;2008-07
6 WU Deng-pan,ZHONG Zhen-guo*,WANG Jin-sheng,WANG Nai-ping,ZHANG Wen-yan,L Liang,QU Ze-qiangCenter of Research & Development of New Drugs,Guangxi Traditional Chinese Medical University,Nanning 530001,Guangxi Zhuang Autonomous Region,China;Influence of PNS on Abilities of Space Search,Learning and Memory in SAMP8 with Alzheimer's Disease[J];Lishizhen Medicine and Materia Medica Research;2008-10
7 ZHONG Zhen-guo,WU Deng-pan,WANG Jin-sheng,ZHANG Wen-yan,Lü Liang,QU Ze-qiang (Center of Research & Development of New Drugs,Guangxi Traditional Chinese Medical University,Nanning 530001,Guangxi Zhuang Autonomous Region,China);Inhibitive Effects of Panax Notoginseng on Expression of APP Protein in SAMP8 Mouse Brain[J];Lishizhen Medicine and Materia Medica Research;2008-11
8 Guo Chaofeng;Yin Shenggao;Xia Meng;Shi Xueli;The First Affiliated Hospital of Guangxi University of Chinese Medicine;College of Pharmacy, Guangxi University of Chinese Medicine;School of Preclinical Medicine, Guangxi University of Chinese Medicine;Science and Technology Department of Guangxi University of Chinese Medicine;;Effects of Albizia Julibrissin Flower Total Flavonoids on Learning and Memory Abilities and Plasma Monoamine Neurotransmitters of Depression Model Rats[J];Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology;2013-06
9 YUAN Xiang-shan,MA Quan-xiang,MAO Ze-shan,WANG Yao-feng,YANG Jie,WEN Xiao-jun(Department of Histology and Embryology Xinxiang Medical University,Xinxiang Henan 453003,China);Changes on the microstructure and the expressions of Caspase-3 and GFAP in mouse hippocampus after acrylamide exposure[J];Journal of Toxicology;2011-03
10 XU Xian-xiang,WU Yang-zheng,SUN Ai-jing,DIAO YongInstitute of Molecular Medicine,Huaqiao University & Engineering Research Center of Molecular Medicine,Ministry of Education,Quanzhou 362021,Fujian,Chin;Phytoestrogen-like effects of herbal saponins[J];Chinese Journal of Clinical Pharmacology and Therapeutics;2011-12
【Secondary Citations】
Chinese Journal Full-text Database 8 Hits
1 WANG Fa-wei 1, WANG Zhi-kuan 1, JIANG Nan 2, TONG Zhan-qi 1, TIAN Jia-he 1, LIU Yi 1,YIN Da-yi 1(1.PLA General Hospital,Beijing 100853,China; 2. Department of Traditional Chinese Medicine of Peking Union Medical College Hospital,Beijing 100730);Clinical study on the effect of Shenlong decoction on vascular dementia[J];Academic Journal of Pla Postgraduate Medical School;2005-02
2 HU Jingqing,WEN Zehuai,LAI Shilong (Senile Encephalopathy Institute,Guangzhou University of TCM,Guanghou 510405, China);A Preliminary Study on the Memory Attribution and Methodology in Morris Water Maze Test[J];JOURNAL OF GUANGZHOU UNIVERSITY OF TRADITIONAL CHINESE MEDICINE;2000-02
3 DENG Jia-gang,HAO Er-wei,GUO Hong-wei,LIU Jun-hui(Guangxi University of TCM,Nanning 530001,China);Analysis of drug law of compound prescription in treating Alzheimer disease[J];Shandong Journal of Traditional Chinese Medicine;2007-06
4 Mu Junxia,Li Xinyi1.Shanxi college of TCM,Taiyuan,Shanxi 030024,China2.The First Hospital of Shanxi Medical University,Taiyuan,Shanxi 030001,China;Effect of Yuanzhi on Learning and memory and AchE Activity of Model Rats with Alzheimer's disease[J];World Journal of Integrated Traditional and Western Medicine;2007-01
5 LI Yu-Bai, AHOU Ji, ZHAO Zhong-gui, et al. (Health Science Center, Hunan Environment Biology College, Hengyang 421001, Hunan;Toxicological Assessment on Safety to Dibutyl Phthalate[J];Practical Preventive Medicine;2005-05
6 LIU Jie-shu,HUANG Li-ya(School of Medicine,Hubei Institute of Nationality,Enshi 445000,China);The Experimental Research and Comparative Analyses of Anti-oxidase Expression to Rat with Alzheimer Disease Enhanced by Radix Ophiopongonis and Radix Polygonummultiflorum[J];Lishizhen Medicine and Materia Medica Research;2007-06
7 RAO Yan, GAO Jie, LAI Shi-long, HU Jing-qing, WANG Qi (Institute of Senile Encephalopathy, the Second School of Medicine, Guangzhou University of Traditional Chinese Medicine, Guangzhou, 510405,China);EFFECTS OF D-GALACTOSE COMBINED WITH LESIONS OF NUCLEUS BASALIS OF MEYNERT ON HIPPOCAMPAL LONG-TERM POTENTIATION AND SYNAPTIC MORPHOLOGY[J];Chinese Journal of Applied Physiology;2002-01
8 Zhong Zhenguo,Qu Zejiang,Wang Naiping,Wang Jinsheng,Xie Zhiguang,Zhang Fengfen,Zhang Wenyan,Lu Zhongpeng(Guangxi College of TCM,Nanning 530001);Protective Effects of Panax notoginseng Saponins against Pathological Lesion of Cholinergic Neuron in Rat Model with Alzheimer's Disease[J];Journal of Chinese Medicinal Materials;2005-02
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