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《Journal of Chinese Physician》 2003-02
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Prevention of Postoperative Abdominal Adhesions by IL-1β and TNFα Antibody in Mice

YUE Shu-Qiang, DOU Ke-feng, YANG Yan-ling.Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032,China  
Objective To assess the ability of interleukin-1 beta (IL-1β) antibody and tumor necrosis factor alpha (TNFα) antibody to prevent postoperative abdominal adhesion formation in mice.Methods 60 BALB/c mice were randomly divided into four groups: normal saline group(n=15), anti-IL-1β group(n=15), anti-TNFα group(n=15),and anti-IL-1β combined with anti-TNFα group(n=15). After an identical peritoneal injury operation, mice were treated using intraperitoneally with either normal saline or corresponding antibody at the time of abdominal closure. The mice were killed 20 days after operation, the abdominal incisions and the development of intra-abdominal adhesions were observed. Adhesion scoring was based on an overall assessment of the extent,location, and type of adhesion.Results Anti-IL-1β combined with anti-TNFα group had significantly lower adhesion scores (0 84±0 19) than that in other groups(P0 01). No incisional hernia was found in abdominal wall in all cases.Conclusion The intraperitoneal administration of IL-1β and TNFα antibody could inhibit postoperative adhesion formation.
【CateGory Index】: R619
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