Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Chinese Physician》 2003-02
Add to Favorite Get Latest Update

Prevention of Postoperative Abdominal Adhesions by IL-1β and TNFα Antibody in Mice

YUE Shu-Qiang, DOU Ke-feng, YANG Yan-ling.Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032,China  
Objective To assess the ability of interleukin-1 beta (IL-1β) antibody and tumor necrosis factor alpha (TNFα) antibody to prevent postoperative abdominal adhesion formation in mice.Methods 60 BALB/c mice were randomly divided into four groups: normal saline group(n=15), anti-IL-1β group(n=15), anti-TNFα group(n=15),and anti-IL-1β combined with anti-TNFα group(n=15). After an identical peritoneal injury operation, mice were treated using intraperitoneally with either normal saline or corresponding antibody at the time of abdominal closure. The mice were killed 20 days after operation, the abdominal incisions and the development of intra-abdominal adhesions were observed. Adhesion scoring was based on an overall assessment of the extent,location, and type of adhesion.Results Anti-IL-1β combined with anti-TNFα group had significantly lower adhesion scores (0 84±0 19) than that in other groups(P0 01). No incisional hernia was found in abdominal wall in all cases.Conclusion The intraperitoneal administration of IL-1β and TNFα antibody could inhibit postoperative adhesion formation.
【CateGory Index】: R619
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 WANG Qiu-jing 1, LU Wen-wei 1, LU Hang 2, LIU Fen 1, YANG Shi-jie 1,HUA Yu-qiang 3, JI Shu-xia 3 (1. Experimental Center of Functional Sciences, School of Basic Medical Sciences, Jilin University,Changchun 130021,China;2.Department of Teaching Center, College of Chemistry,Jilin University, Changchun 130021,China;3.BaiShan Pharmaceutical LimitedCompany of Tonghua City,Jilin Province,Tonghua 134000,China);Effects of QiDong YiXin on hemodynamics and acute myocardial ischemia in anesthetic dogs[J];Journal of Jilin University of (Medicine Edition);2004-05
2 Wu Jianxin et al(Department of Physiology, Dali Medical College, Dali 671000);Effect of Xinmailong on Lipid Peroxidation in Experimental Rabbits with Lung Injury[J];JOURNAL OF DALI MEDICAL COLLEGE;1998-03
3 Si-wang WANG Institute of Materia Medica, School of Pharmacy,Fourth Military Medical University, Xi'an 7l0033, China;Molecule of Chinese hebral drugs and molecular chinese herbal drugs[J];Journal of the Fourth Military Medical University;2008-18
4 ZHOUXiang,YINBing-sheng ResearchCenterof Electrocardiology,FirstMilitaryMedicalUniversity,Guangzhou510515,China;Comparison of pseudo Q wave occurrence and distribution on the body surface in New Zealand rabbit recorded by Wilson lead and head-chest lead[J];Journal of First Military Medical University;2002-03
5 YU Zhe,FAN Qing-yu,ZHANG Ting(Center of Orthopedic Surgery,Orthopedics Oncology Institute of Chinese PLA,Tangdu Hospital,Xi’an,Shaanxi,710038,China);Establishment of Rat Model of Osteosarcoma[J];Progress In Veterinary Medicine;2005-02
6 SONG Min,WANG Wei,WEN Wen(College of Life Science,Henan University,Kaifeng,Henan,475004,China);Study of Chronic Liver Injury Model Induced with Carbon Tetrachloride and Alcohol in Mice[J];Progress in Veterinary Medicine;2008-S1
7 JIE Ya1,ZHU Shao-hua1,JIANG Yan-wei2,ZHANG Lei1,FAN Fan1 (1. Department of Forensic Medicine,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China; 2. Tianjin Institute of Criminal Science and Technology,Tianjin 300193,China);Changes of RyR_2 mRNA Expression in Rats Suffering from Acute Myocardial Ischemia[J];Journal of Forensic Medicine;2008-05
8 Liu Taowen,Cao Minghua,Wen Shangwu//Institute of Bioengineering,Guilin Medical College(541004);Study on the Changes in Plasma Fibronectin Level of Poisoned Patients Following Agkistrodon acutus Bite[J];ACTA MEDICINAE SINICA;1998-02
9 GAO Shaofang,LI Diangui,JIA Yansu.Hebei Medical University,Hebei,Shijiazhuang 050000;Effect of HXTML on myocardial ischemic rats[J];Hebei Journal of Traditional Chinese Medicine;2008-11
10 YANG Yan-ling 1 ,XU Xiao-ping 2 ,LI Kai-zong 1 ,DOU Ke-feng 1 ,YUE Shu-qiang 1 (1.Department of Hepatobiliary Surgery,Xijing Hospital,the Fourth Military Medical University,Xi'an 710032,Shaanxi,China; 2. Department of General Surgery,Zhujiang Hospital,the First Military Medical University,Guangzhou 510282,Guangdong,China);Prevention of postoperative abdominal adhesions by ulinastatin and interleukin-1 beta antibody in mice[J];Journal of Medical Postgraduates;2004-03
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved